FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976363494> ?p ?o ?g. }

• W1976363494 endingPage "38" @default.
• W1976363494 startingPage "32" @default.
• W1976363494 abstract "Activation of T cells through the T-cell receptor (TCR) induces the expression of Fas Ligand (CD95L). In turn, CD95L binds to the Fas receptor (CD95) and rapidly induces apoptosis in cycling cells. This interaction is involved in the elimination of reactive lymphocytes during an immune response. However, TCR activation cannot always trigger apoptosis because an effective immune response would then be compromised. Here we show that a short (2 to 3 h) activation of T cells through the TCR simultaneously induces an increase in CD95L mRNA and a dramatic decrease in caspase-8 mRNA levels and proteolytic activity in human CD8(+) T cells. In addition, there is a small reduction in CD95 mRNA and CD95 levels on the cell surface. We found that preactivation of T cells protected them from apoptosis induced by either religation of the TCR or direct exposure to CD95L. These results suggest a mechanism by which cycling CD95-sensitive peripheral T cells, become protected from CD95 mediated deletion when actively engaged in the specific recognition of target cells." @default.
• W1976363494 created "2016-06-24" @default.
• W1976363494 creator A5007898120 @default.
• W1976363494 creator A5061687655 @default.
• W1976363494 creator A5070276458 @default.
• W1976363494 creator A5072313658 @default.
• W1976363494 creator A5088917458 @default.
• W1976363494 date "2001-01-01" @default.
• W1976363494 modified "2023-09-30" @default.
• W1976363494 title "TCR stimulation protects CD8+ T cells from CD95 mediated apoptosis" @default.
• W1976363494 cites W1500281207 @default.
• W1976363494 cites W1516581843 @default.
• W1976363494 cites W1972805802 @default.
• W1976363494 cites W1975155851 @default.
• W1976363494 cites W1983806918 @default.
• W1976363494 cites W1998415250 @default.
• W1976363494 cites W2002503549 @default.
• W1976363494 cites W2002733542 @default.
• W1976363494 cites W2004645606 @default.
• W1976363494 cites W2017728303 @default.
• W1976363494 cites W2022393030 @default.
• W1976363494 cites W2023809975 @default.
• W1976363494 cites W2035330294 @default.
• W1976363494 cites W2041466047 @default.
• W1976363494 cites W2055506415 @default.
• W1976363494 cites W2068528427 @default.
• W1976363494 cites W2080568999 @default.
• W1976363494 cites W2086313080 @default.
• W1976363494 cites W2119292350 @default.
• W1976363494 cites W2120633856 @default.
• W1976363494 cites W2124446900 @default.
• W1976363494 cites W2129971278 @default.
• W1976363494 cites W2132156332 @default.
• W1976363494 cites W2132825839 @default.
• W1976363494 cites W2135400695 @default.
• W1976363494 cites W2152213870 @default.
• W1976363494 cites W2154757961 @default.
• W1976363494 cites W2156750847 @default.
• W1976363494 cites W309166525 @default.
• W1976363494 doi "https://doi.org/10.1016/s0198-8859(00)00223-8" @default.
• W1976363494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11165713" @default.
• W1976363494 hasPublicationYear "2001" @default.
• W1976363494 type Work @default.
• W1976363494 sameAs 1976363494 @default.
• W1976363494 citedByCount "11" @default.
• W1976363494 countsByYear W19763634942023 @default.
• W1976363494 crossrefType "journal-article" @default.
• W1976363494 hasAuthorship W1976363494A5007898120 @default.
• W1976363494 hasAuthorship W1976363494A5061687655 @default.
• W1976363494 hasAuthorship W1976363494A5070276458 @default.
• W1976363494 hasAuthorship W1976363494A5072313658 @default.
• W1976363494 hasAuthorship W1976363494A5088917458 @default.
• W1976363494 hasConcept C153911025 @default.
• W1976363494 hasConcept C154317977 @default.
• W1976363494 hasConcept C167672396 @default.
• W1976363494 hasConcept C170493617 @default.
• W1976363494 hasConcept C185592680 @default.
• W1976363494 hasConcept C190283241 @default.
• W1976363494 hasConcept C19317047 @default.
• W1976363494 hasConcept C202751555 @default.
• W1976363494 hasConcept C203014093 @default.
• W1976363494 hasConcept C2776090121 @default.
• W1976363494 hasConcept C3031857 @default.
• W1976363494 hasConcept C31573885 @default.
• W1976363494 hasConcept C55493867 @default.
• W1976363494 hasConcept C86803240 @default.
• W1976363494 hasConcept C8891405 @default.
• W1976363494 hasConcept C95444343 @default.
• W1976363494 hasConceptScore W1976363494C153911025 @default.
• W1976363494 hasConceptScore W1976363494C154317977 @default.
• W1976363494 hasConceptScore W1976363494C167672396 @default.
• W1976363494 hasConceptScore W1976363494C170493617 @default.
• W1976363494 hasConceptScore W1976363494C185592680 @default.
• W1976363494 hasConceptScore W1976363494C190283241 @default.
• W1976363494 hasConceptScore W1976363494C19317047 @default.
• W1976363494 hasConceptScore W1976363494C202751555 @default.
• W1976363494 hasConceptScore W1976363494C203014093 @default.
• W1976363494 hasConceptScore W1976363494C2776090121 @default.
• W1976363494 hasConceptScore W1976363494C3031857 @default.
• W1976363494 hasConceptScore W1976363494C31573885 @default.
• W1976363494 hasConceptScore W1976363494C55493867 @default.
• W1976363494 hasConceptScore W1976363494C86803240 @default.
• W1976363494 hasConceptScore W1976363494C8891405 @default.
• W1976363494 hasConceptScore W1976363494C95444343 @default.
• W1976363494 hasIssue "1" @default.
• W1976363494 hasLocation W19763634941 @default.
• W1976363494 hasLocation W19763634942 @default.
• W1976363494 hasOpenAccess W1976363494 @default.
• W1976363494 hasPrimaryLocation W19763634941 @default.
• W1976363494 hasRelatedWork W1808357240 @default.
• W1976363494 hasRelatedWork W2016887421 @default.
• W1976363494 hasRelatedWork W2025766338 @default.
• W1976363494 hasRelatedWork W2031740266 @default.
• W1976363494 hasRelatedWork W2063492259 @default.
• W1976363494 hasRelatedWork W2106875608 @default.
• W1976363494 hasRelatedWork W2181431303 @default.
• W1976363494 hasRelatedWork W2287738525 @default.
• W1976363494 hasRelatedWork W4229027259 @default.

• next