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- W1976366940 abstract "Objective: The present study was aimed to determine whether the ethanolic extract of Garcinia mangostana (mangosteen) fruit pericarp (EEMP) changes several markers of inflammation, such as nuclear factor kappaB (NF-κB) p65/p50 distribution, tumor necrosis factor (TNF)-α levels, and nitric oxide (NO) in the atherosclerotic rats model. Methods: Thirty male Wistar rats were divided into five groups (n = 6 each), including standard diet (control group), hypercholesterolemic diet (HD) group, HD + EEMP at dose of 200, 400 and 800 mg/kg body weight (BW). Analysis of NF-κB p65/p50 distribution was done by imunnohistochemistry method. The levels of TNF-α and NO were measured by ELISA. Results: High cholesterol diet significantly increased NF-κB p65/p50 distribution, TNF-α levels and NO levels compared with control group. The levels of NF-κB p65/p50 distribution was significantly decreased in EEGM-treated group at doses 200 and 800 mg/kg BW than that in atherosclerosis group. The levels of NO and TNF-α were significantly decreased in EEGM-treated group at all doses compared to atherosclerosis group, but did not reach levels at standard diet. Conclusions: The present data suggests that EEMP inhibits inflammation in atherosclerotic rats due to inhibition of distribution NF-κB p65/p50 into the nucleus and decreases TNF-α and NO levels." @default.
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- W1976366940 date "2013-01-01" @default.
- W1976366940 modified "2023-10-18" @default.
- W1976366940 title "Cathecins in ethanolic extracts of <i>Garcinia mangostana</i> fruit pericarp and anti-inflammatory effect in atherosclerotic rats" @default.
- W1976366940 doi "https://doi.org/10.5455/jeim.250313.br.015" @default.
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