Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976373486> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1976373486 endingPage "1041" @default.
- W1976373486 startingPage "1037" @default.
- W1976373486 abstract "The enzyme carbonic anhydrase has been suggested as a critical participant in osteoclast-mediated bone resorption. In humoral hypercalcemia of malignancy (HHM) intense osteoclastic bone resorption is principally responsible for the observed hypercalcemia. We therefore undertook to examine the effect of the carbonic anhydrase inhibitor acetazolamide on the hypercalcemia induced by the H500 Leydig cell tumor in Fisher rats, a well-described model of HHM. Acetazolamide treatment for 10 h at 10 mg/h resulted in a significant fall in serum calcium in the five drug-treated animals (14.2 +/- 0.9 to 11.5 +/- 0.1 mg/dl, p less than 0.05). Conversely, the six animals infused with vehicle alone showed a significant rise in serum calcium (12.5 +/- 0.5 to 13.8 +/- 0.1 mg/dl, p less than 0.05). At the end of the infusion, the acetazolamide-treated animals had a significantly lower mean serum calcium than those receiving vehicle alone (11.5 +/- 0.1 versus 13.8 +/- 0.1, p less than 0.05). There was no significant change in serum phosphorus, urine calcium, urine phosphorus, or nephrogenous cyclic AMP excretion between the two groups. Acetazaolamide and HTS 5-(3-hydroxybenzoyl)-2-thiophenesulfonamide, another carbonic anhydrase inhibitor, both significantly inhibited in vitro bone resorption induced by 5 X 10(-9) M 36Tyr(1-36)-PTHrP-amide (PTHrP, parathyroid hormone-related protein). Acetazolamide also inhibited the resorption induced by 10(-8) M (1-141)-PTHrP and 2.5 X 10(-9) M (1-74)-PTHrP. We conclude that acetazolamide is effective in lowering the serum calcium in animals with humoral hypercalcemia of malignancy. The data are consistent with the hypothesis that the mechanism of action for this effect is direct inhibition of osteoclast-mediated bone resorption." @default.
- W1976373486 created "2016-06-24" @default.
- W1976373486 creator A5001727280 @default.
- W1976373486 creator A5014900608 @default.
- W1976373486 creator A5061881760 @default.
- W1976373486 creator A5075013519 @default.
- W1976373486 date "2009-12-03" @default.
- W1976373486 modified "2023-10-13" @default.
- W1976373486 title "Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase" @default.
- W1976373486 cites W1966817891 @default.
- W1976373486 cites W1982166700 @default.
- W1976373486 cites W1986218086 @default.
- W1976373486 cites W1994772193 @default.
- W1976373486 cites W1997986050 @default.
- W1976373486 cites W2004067137 @default.
- W1976373486 cites W2007671540 @default.
- W1976373486 cites W2009904653 @default.
- W1976373486 cites W2027645483 @default.
- W1976373486 cites W2055439515 @default.
- W1976373486 cites W2059199762 @default.
- W1976373486 cites W2061872269 @default.
- W1976373486 cites W2062179808 @default.
- W1976373486 cites W2075356469 @default.
- W1976373486 cites W2089012867 @default.
- W1976373486 cites W2092973229 @default.
- W1976373486 cites W2106382407 @default.
- W1976373486 cites W2139090888 @default.
- W1976373486 cites W2615573241 @default.
- W1976373486 doi "https://doi.org/10.1002/jbmr.5650051007" @default.
- W1976373486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1964358" @default.
- W1976373486 hasPublicationYear "2009" @default.
- W1976373486 type Work @default.
- W1976373486 sameAs 1976373486 @default.
- W1976373486 citedByCount "4" @default.
- W1976373486 countsByYear W19763734862015 @default.
- W1976373486 crossrefType "journal-article" @default.
- W1976373486 hasAuthorship W1976373486A5001727280 @default.
- W1976373486 hasAuthorship W1976373486A5014900608 @default.
- W1976373486 hasAuthorship W1976373486A5061881760 @default.
- W1976373486 hasAuthorship W1976373486A5075013519 @default.
- W1976373486 hasConcept C126322002 @default.
- W1976373486 hasConcept C131075544 @default.
- W1976373486 hasConcept C134018914 @default.
- W1976373486 hasConcept C146562846 @default.
- W1976373486 hasConcept C160160445 @default.
- W1976373486 hasConcept C181199279 @default.
- W1976373486 hasConcept C185592680 @default.
- W1976373486 hasConcept C2775914622 @default.
- W1976373486 hasConcept C2777405951 @default.
- W1976373486 hasConcept C2778076468 @default.
- W1976373486 hasConcept C2780787237 @default.
- W1976373486 hasConcept C519063684 @default.
- W1976373486 hasConcept C55493867 @default.
- W1976373486 hasConcept C673006 @default.
- W1976373486 hasConcept C71924100 @default.
- W1976373486 hasConceptScore W1976373486C126322002 @default.
- W1976373486 hasConceptScore W1976373486C131075544 @default.
- W1976373486 hasConceptScore W1976373486C134018914 @default.
- W1976373486 hasConceptScore W1976373486C146562846 @default.
- W1976373486 hasConceptScore W1976373486C160160445 @default.
- W1976373486 hasConceptScore W1976373486C181199279 @default.
- W1976373486 hasConceptScore W1976373486C185592680 @default.
- W1976373486 hasConceptScore W1976373486C2775914622 @default.
- W1976373486 hasConceptScore W1976373486C2777405951 @default.
- W1976373486 hasConceptScore W1976373486C2778076468 @default.
- W1976373486 hasConceptScore W1976373486C2780787237 @default.
- W1976373486 hasConceptScore W1976373486C519063684 @default.
- W1976373486 hasConceptScore W1976373486C55493867 @default.
- W1976373486 hasConceptScore W1976373486C673006 @default.
- W1976373486 hasConceptScore W1976373486C71924100 @default.
- W1976373486 hasIssue "10" @default.
- W1976373486 hasLocation W19763734861 @default.
- W1976373486 hasLocation W19763734862 @default.
- W1976373486 hasOpenAccess W1976373486 @default.
- W1976373486 hasPrimaryLocation W19763734861 @default.
- W1976373486 hasRelatedWork W1976718122 @default.
- W1976373486 hasRelatedWork W1989717371 @default.
- W1976373486 hasRelatedWork W2004067137 @default.
- W1976373486 hasRelatedWork W2045729927 @default.
- W1976373486 hasRelatedWork W2060273006 @default.
- W1976373486 hasRelatedWork W2062354750 @default.
- W1976373486 hasRelatedWork W2064914389 @default.
- W1976373486 hasRelatedWork W2141336834 @default.
- W1976373486 hasRelatedWork W2354292748 @default.
- W1976373486 hasRelatedWork W2413000244 @default.
- W1976373486 hasVolume "5" @default.
- W1976373486 isParatext "false" @default.
- W1976373486 isRetracted "false" @default.
- W1976373486 magId "1976373486" @default.
- W1976373486 workType "article" @default.