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• W1976388701 abstract "MicroRNAs are currently being extensively studied due to their important role as post-transcriptional regulators. During miRNA biogenesis, precursors undergo two cleavage steps performed by Drosha-DGCR8 (Microprocessor) cleaving of pri-miRNA to produce pre-miRNA and Dicer-mediated cleaving to create mature miRNA. Genetic variants within human miRNA regulome have been shown to influence miRNA expression, target interaction and to affect the phenotype. In this study, we reviewed the literature, existing bioinformatics tools and catalogs associated with polymorphic miRNA regulome, and organized them into four categories: (1) polymorphisms located within miRNA genes (miR-SNPs), (2) transcription factor-binding sites/miRNA regulatory regions (miR-rSNPs), (3) miRNA target sites (miR-TS-SNPs), and 4. miRNA silencing machinery (miR-SM-SNPs). Since the miR-SM-SNPs have not been systematically studied yet, we have collected polymorphisms associated with miRNA silencing machinery. We have developed two catalogs containing genetic variability within: (1) genes encoding three main catalytic components of the silencing machinery, DROSHA, DGCR8, and DICER1; (2) miRNA genes itself, overlapping Drosha and Dicer cleavage sites. The developed resource of polymorphisms is available online (http://www.integratomics-time.com/miRNA-regulome) and will be useful for further functional studies and development of biomarkers associated with diseases and phenotypic traits." @default.
• W1976388701 created "2016-06-24" @default.
• W1976388701 creator A5014673732 @default.
• W1976388701 creator A5057977751 @default.
• W1976388701 creator A5077110623 @default.
• W1976388701 date "2014-09-15" @default.
• W1976388701 modified "2023-09-26" @default.
• W1976388701 title "Genetic variability of micro <scp>RNA</scp> regulome in human" @default.
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• W1976388701 doi "https://doi.org/10.1002/mgg3.110" @default.
• W1976388701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4299713" @default.
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• W1976388701 hasPublicationYear "2014" @default.
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