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• W1976416315 endingPage "841" @default.
• W1976416315 startingPage "828" @default.
• W1976416315 abstract "Nine nicotinic receptor subunits are expressed in the central nervous system indicating that a variety of nicotinic acetylcholine receptors (nAChR) may be assembled. A useful method with which to identify putative nAChR is radioligand binding. In the current study the binding of [125I]α-bungarotoxin, [125I]α-conotoxinMII, 5[125I]-3-((2S)-azetidinylmethoxy)pyridine (A-85380), and [125I]epibatidine has been measured autoradiographically to provide data on many nAChR binding sites. Each binding site was evaluated semi-quantitatively for samples prepared from wild-type and α2, α4, α6, α7, β2, β4, α5 and β3 null mutant mice. Deletion of the α7 subunit completely and selectively eliminated [125I]α-bungarotoxin binding. The binding of [125I]α-conotoxinMII was eliminated in most brain regions by deletion of either the α6 or β2 subunit and is reduced by deletion of either the α4 or β3 subunit. The binding of 5[125I]A-85380 was completely eliminated by deletion of the β2 subunit and significantly reduced by deletion of the α4 subunit. Most, but not all, α4-independent sites require expression of the α6 subunit. The effect of gene deletion on total [125I]epibatidine binding was very similar to that on [125I]A-85380 binding. [125I]Epibatidine also labels β4* nAChR, which was readily apparent for incubations conducted in the presence of 100 nM cytisine. The effects of α3 gene deletion could not be evaluated, but persistence of residual sites implies the expression of α3* nAChR. Taken together these results confirm and extend previously published evaluations of the effect of nAChR gene deletion and help to define the nAChR subtypes measurable by ligand binding." @default.
• W1976416315 created "2016-06-24" @default.
• W1976416315 creator A5033596146 @default.
• W1976416315 creator A5080448364 @default.
• W1976416315 date "2011-10-01" @default.
• W1976416315 modified "2023-10-17" @default.
• W1976416315 title "An autoradiographic survey of mouse brain nicotinic acetylcholine receptors defined by null mutants" @default.
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• W1976416315 doi "https://doi.org/10.1016/j.bcp.2011.04.019" @default.
• W1976416315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3162045" @default.
• W1976416315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21575611" @default.
• W1976416315 hasPublicationYear "2011" @default.
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