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• W1976419781 abstract "In Brief Objective: To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy. Background: HCC recurrence frequently occurs within the first year after hepatectomy, probably due to circulating tumor cells that have been shed from the primary tumor before hepatectomy. Because CSCs are more likely to initiate tumor growth than mature cancer cells, a high level of circulating CSCs may be a hint for HCC recurrence. Methods: Multicolor flow cytometry was used to detect the number of circulating CSCs (CD45−CD90+CD44+) in the peripheral circulation of 82 HCC patients 1 day before hepatectomy. The patients were monitored by CT or MRI for recurrence every 3 months. Results: Forty-one (50%) patients had recurrence after a median follow-up period of 13.2 months (range, 1.3–57.1 months). Patients with recurrence had a higher median level of circulating CSCs than patients without recurrence (0.02% vs. 0.01%; P < 0.0001). Circulating CSCs > 0.01% predicted intrahepatic recurrence (relative risk 3.54; 95% CI, 1.41–8.88; P = 0.007) and extrahepatic recurrence (relative risk 10.15; 95% CI, 3–34.4; P = 0.0002). Patients with >0.01% circulating CSCs had a lower 2-year recurrence-free survival rate (22.7% vs. 64.2%; P < 0.0001) and overall survival rate (58.5% vs. 94.1%; P = 0.0005) than patients with ≤0.01% circulating CSCs. On multivariable analysis, circulating CSCs > 0.01%, tumor stage and tumor size were independent factors predicting recurrence-free survival. Conclusions: Circulating CSCs predicted posthepatectomy HCC recurrence with high accuracy. They may be the target of eradication in the prevention of posthepatectomy HCC metastasis and recurrence. Recurrence of HCC after hepatectomy could be due to cancer stem cells (CSCs) migrating into the blood stream from the tumor before surgery. Using CD45−CD90+CD44+ as markers, circulating CSCs of HCC were identified. The level of >0.01% circulating CSCs predicted HCC recurrence after hepatectomy with high accuracy." @default.
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• W1976419781 date "2011-10-01" @default.
• W1976419781 modified "2023-10-18" @default.
• W1976419781 title "Prediction of Posthepatectomy Recurrence of Hepatocellular Carcinoma by Circulating Cancer Stem Cells" @default.
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• W1976419781 doi "https://doi.org/10.1097/sla.0b013e3182300a1d" @default.
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