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• W1976421949 abstract "Female Drosophila with the spinster mutation repel courting males and rarely mate. Here we show that the non-copulating phenotype can be recapitulated by the elimination of spinster functions from either spin-A or spin-D neuronal clusters, in the otherwise wild-type (spinster heterozygous) female brain. Spin-D corresponds to the olfactory projection neurons with dendrites in the antennal lobe VA1v glomerulus that is fruitless-positive, sexually dimorphic and responsive to fly odour. Spin-A is a novel local neuron cluster in the suboesophageal ganglion, which is known to process contact chemical pheromone information and copulation-related signals. A slight reduction in spinster expression to a level with a minimal effect is sufficient to shut off female sexual receptivity if the dominant-negative mechanistic target of rapamycin is simultaneously expressed, although the latter manipulation alone has only a marginal effect. We propose that spin-mediated mechanistic target of rapamycin signal transduction in these neurons is essential for females to accept the courting male." @default.
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• W1976421949 date "2013-05-07" @default.
• W1976421949 modified "2023-10-16" @default.
• W1976421949 title "Select interneuron clusters determine female sexual receptivity in Drosophila" @default.
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• W1976421949 doi "https://doi.org/10.1038/ncomms2837" @default.
• W1976421949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3674241" @default.
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