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• W1976422963 abstract "Low dialysate sodium concentrations can reduce postdialysis thirst and serum sodium activity, but patients typically experience dialysis hypotension, fatigue, disequilibrium, and cramps. High-sodium hemodialysis minimizes dialysis disequilibrium but increases the serum sodium activity of most patients. Programmed variable-sodium dialysis can minimize dialysis discomfort but may also alter the sodium kinetics from those of high-sodium dialysis. We designed a cross-over study with random order assignment to determine whether a variable-sodium dialysis program could reduce the blood pressure of dialysis patients without increasing dialysis morbidity. Dialysis with a dialysate sodium of 140 mEq/L was compared with dialysis with a programmed exponential decrease of dialysate sodium from 155 mEq/L to 135 mEq/L. Dialysate sodium was then held constant at 135 mEq/L for the final half hour of dialysis. Eighteen patients completed the 7-month study, each receiving 3.5 months of experimental and 3.5 months of standard therapy. Programmed variable-sodium dialysis resulted in a reduction in antihypertensive drug use without alterations in predialysis blood pressure, interdialytic weight gain, ultrafiltration tolerance, or the frequency of symptomatic dialysis cramps or hypotension. Patients did, however, have lower postdialysis standing blood pressures and higher postdialysis target weights during programmed variable-sodium dialysis." @default.
• W1976422963 created "2016-06-24" @default.
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• W1976422963 date "1997-03-01" @default.
• W1976422963 modified "2023-10-02" @default.
• W1976422963 title "Dialysate sodium delivery can alter chronic blood pressure management" @default.
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• W1976422963 doi "https://doi.org/10.1016/s0272-6386(97)90199-2" @default.
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