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- W1976427666 abstract "The discovery of mutations in the epidermal growth factor receptor (EGFR) has marked a dramatic change in the treatment of lung cancer. 1 Patients with EGFR-mutant lung adenocarcinoma receiving EGFR inhibitors have a median overall survival of more than 2 years, contrasting with the survival of unselected patients receiving platinum-based combinations (approximately 12 months). 2-4 In the study by Ramalingam et al, 5 the report that accompanies this article, a novel irreversible ERBB family inhibitor, dacomitinib, improved progression-free survival (PFS) compared with erlotinib in unselected patients with non–small-cell lung cancer (NSCLC) without prior EGFR-directed therapy. Here, we provide a brief overview of the biology of EGFR signaling and inhibition and discuss briefly the topic of reversible versus covalent EGFR inhibition in lung cancer." @default.
- W1976427666 created "2016-06-24" @default.
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- W1976427666 date "2012-09-20" @default.
- W1976427666 modified "2023-10-16" @default.
- W1976427666 title "Epidermal Growth Factor Receptor (EGFR) Signaling and Covalent EGFR Inhibition in Lung Cancer" @default.
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- W1976427666 doi "https://doi.org/10.1200/jco.2012.43.1825" @default.
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