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- W1976445538 abstract "Chemical carcinogens and ionizing radiation induce DNA modifications and strand breaks in cells. This damage is reported to be affected by chromatin proteins or chromatin of a higher structure order. To compare the sensitivity of transcriptionally active and inactive genes on chromatin toward DNA-damaging agents, we treated normal human fibroblasts (WI-38) cells with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), X-ray, 4-hydroxyaminoquinoline 1-oxide or N-acetoxy-2-acetylaminofluorene, and high molecular weight DNA was isolated. After digestion with EcoRI to completion, the DNA was electrophoresed on an alkaline agarose gel, blotted on a nitrocellulose filter and hybridized with a transcriptionally active gene probe (human type I(α2) procollagen gene) or an inactive gene probe (human β-globin gene). The results show that both genes are similarly modified by these agents. Repair of DNA damage caused by MNNG also occurred similarly in collagen and β-globin genes after removal of MNNG." @default.
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- W1976445538 date "1984-04-01" @default.
- W1976445538 modified "2023-09-23" @default.
- W1976445538 title "Transcriptionally active and inactive genes are similarly modified by chemical carcinogens or X-ray in normal human fibroblasts" @default.
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- W1976445538 doi "https://doi.org/10.1016/0167-4781(84)90093-9" @default.
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