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- W1976451129 abstract "A new series of water-soluble tetravalent glycoclusters incorporating β-lactosyl residues attached to a central calix[4]arene core was synthesised using azide–alkyne Cu(I)-catalysed cycloaddition (‘click chemistry’). Carbohydrate moieties were attached either to the upper or lower rim of rigid cone-shaped or partial cone macrocycles via 14–21 atom spacer arms. The glycoclusters with a C4-symmetrical arrangement of β-lactosyl residues showed trypanocidal activity, with one of them showing comparable activity to established anti-trypanosomal drug benznidazole in in vitro anti-parasite assays." @default.
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- W1976451129 date "2011-08-01" @default.
- W1976451129 modified "2023-10-14" @default.
- W1976451129 title "Glycoclusters presenting lactose on calix[4]arene cores display trypanocidal activity" @default.
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- W1976451129 doi "https://doi.org/10.1016/j.tet.2011.06.065" @default.
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