FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976465544> ?p ?o ?g. }

• W1976465544 endingPage "983" @default.
• W1976465544 startingPage "976" @default.
• W1976465544 abstract "Cardiovascular disease, the most common cause of death with a functioning graft among kidney transplant recipients, can be exacerbated by immunosuppressive drugs, particularly the calcineurin inhibitors. Belatacept, a selective co-stimulation blocker, may provide a better cardiovascular/metabolic risk profile than current immunosuppressants.Cardiovascular and metabolic endpoints from two Phase III studies (BENEFIT and BENEFIT-EXT) of belatacept-based regimens in kidney transplant recipients were assessed at month 12. Each study assessed belatacept in more intensive (MI) and less intensive (LI) regimens versus cyclosporine A (CsA). These secondary endpoints included changes in blood pressure, changes in serum lipids, and the incidence of new-onset diabetes after transplant (NODAT).A total of 1209 patients were randomized and transplanted across the two studies. Mean systolic blood pressure was 6 to 9 mm Hg lower and mean diastolic blood pressure was 3 to 4 mm Hg lower in the MI and LI groups versus CsA (P ≤ 0.002) across both studies at month 12. Non-HDL cholesterol was lower in the belatacept groups versus CsA (P<0.01 MI or LI vs. CsA in each study). Serum triglycerides were lower in the belatacept groups versus CsA (P<0.02 MI or LI vs. CsA in each study). NODAT occurred less often in the belatacept groups versus CsA in a prespecified pooled analysis (P<0.05 MI or LI vs. CsA).At month 12, belatacept regimens were associated with better cardiovascular and metabolic risk profiles, with lower blood pressure and serum lipids and less NODAT versus CsA. The overall profile of belatacept will continue to be assessed over the 3-year trials." @default.
• W1976465544 created "2016-06-24" @default.
• W1976465544 creator A5026789430 @default.
• W1976465544 creator A5038511140 @default.
• W1976465544 creator A5038670455 @default.
• W1976465544 creator A5040457368 @default.
• W1976465544 creator A5040530313 @default.
• W1976465544 creator A5045454594 @default.
• W1976465544 creator A5051331713 @default.
• W1976465544 creator A5057907715 @default.
• W1976465544 creator A5062306820 @default.
• W1976465544 creator A5065115970 @default.
• W1976465544 creator A5075848442 @default.
• W1976465544 creator A5083578174 @default.
• W1976465544 creator A5086232647 @default.
• W1976465544 creator A5088750611 @default.
• W1976465544 creator A5091033598 @default.
• W1976465544 date "2011-05-15" @default.
• W1976465544 modified "2023-10-10" @default.
• W1976465544 title "Belatacept-Based Regimens Are Associated With Improved Cardiovascular and Metabolic Risk Factors Compared With Cyclosporine in Kidney Transplant Recipients (BENEFIT and BENEFIT-EXT Studies)" @default.
• W1976465544 cites W180946569 @default.
• W1976465544 cites W1891715432 @default.
• W1976465544 cites W1967953604 @default.
• W1976465544 cites W1977589132 @default.
• W1976465544 cites W1979815592 @default.
• W1976465544 cites W1981002254 @default.
• W1976465544 cites W1982444046 @default.
• W1976465544 cites W1982966161 @default.
• W1976465544 cites W1988753648 @default.
• W1976465544 cites W1999444321 @default.
• W1976465544 cites W2005426088 @default.
• W1976465544 cites W2007618996 @default.
• W1976465544 cites W2013058868 @default.
• W1976465544 cites W2014106235 @default.
• W1976465544 cites W2014413823 @default.
• W1976465544 cites W2021881836 @default.
• W1976465544 cites W2023370629 @default.
• W1976465544 cites W2027371366 @default.
• W1976465544 cites W2029046028 @default.
• W1976465544 cites W2029340370 @default.
• W1976465544 cites W2030202502 @default.
• W1976465544 cites W2031456149 @default.
• W1976465544 cites W2033964625 @default.
• W1976465544 cites W2036800893 @default.
• W1976465544 cites W2038148357 @default.
• W1976465544 cites W2040318571 @default.
• W1976465544 cites W2040904160 @default.
• W1976465544 cites W2044519782 @default.
• W1976465544 cites W2044600432 @default.
• W1976465544 cites W2049745810 @default.
• W1976465544 cites W2053797842 @default.
• W1976465544 cites W2054827086 @default.
• W1976465544 cites W2062022521 @default.
• W1976465544 cites W2066214122 @default.
• W1976465544 cites W2071847363 @default.
• W1976465544 cites W2072859187 @default.
• W1976465544 cites W2075025454 @default.
• W1976465544 cites W2077684987 @default.
• W1976465544 cites W2078851746 @default.
• W1976465544 cites W2078939327 @default.
• W1976465544 cites W2084126045 @default.
• W1976465544 cites W2087317980 @default.
• W1976465544 cites W2087351502 @default.
• W1976465544 cites W2089103283 @default.
• W1976465544 cites W2096811886 @default.
• W1976465544 cites W2098362601 @default.
• W1976465544 cites W2099192717 @default.
• W1976465544 cites W2107943520 @default.
• W1976465544 cites W2109439585 @default.
• W1976465544 cites W2115504370 @default.
• W1976465544 cites W2125786054 @default.
• W1976465544 cites W2127668399 @default.
• W1976465544 cites W2137780217 @default.
• W1976465544 cites W2140501857 @default.
• W1976465544 cites W2143722971 @default.
• W1976465544 cites W2143954917 @default.
• W1976465544 cites W2145632027 @default.
• W1976465544 cites W2168312482 @default.
• W1976465544 cites W2329006805 @default.
• W1976465544 cites W2334899541 @default.
• W1976465544 cites W4238251256 @default.
• W1976465544 cites W4248229520 @default.
• W1976465544 doi "https://doi.org/10.1097/tp.0b013e31820c10eb" @default.
• W1976465544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21372756" @default.
• W1976465544 hasPublicationYear "2011" @default.
• W1976465544 type Work @default.
• W1976465544 sameAs 1976465544 @default.
• W1976465544 citedByCount "154" @default.
• W1976465544 countsByYear W19764655442012 @default.
• W1976465544 countsByYear W19764655442013 @default.
• W1976465544 countsByYear W19764655442014 @default.
• W1976465544 countsByYear W19764655442015 @default.
• W1976465544 countsByYear W19764655442016 @default.
• W1976465544 countsByYear W19764655442017 @default.
• W1976465544 countsByYear W19764655442018 @default.
• W1976465544 countsByYear W19764655442019 @default.
• W1976465544 countsByYear W19764655442020 @default.
• W1976465544 countsByYear W19764655442021 @default.

• next