FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976467306> ?p ?o ?g. }

• W1976467306 endingPage "952" @default.
• W1976467306 startingPage "944" @default.
• W1976467306 abstract "It has been proposed that proinflammatory mechanisms are involved in the pathogenesis of brain edema in acute liver failure (ALF). The aim of this study was to assess the contribution of cerebral inflammation to the neurologic complications of ALF and to assess the antiinflammatory effect of mild hypothermia. Upregulation of CD11b/c immunoreactivity, consistent with microglial activation, was observed in the brains of ALF rats at coma stages of encephalopathy. Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) mRNAs were increased two to threefold in the brains of ALF rats compared with that in sham-operated controls. The magnitude of increased expression of proinflammatory cytokines in the brain was correlated with the progression of encephalopathy and the onset of brain edema. Significant increases in IL-1β, IL-6, and TNF-α levels were also found in the sera and cerebrospinal fluid (CSF) of these animals. Mild hypothermia delayed the onset of encephalopathy, prevented brain edema, and concomitantly attenuated plasma, brain, and CSF proinflammatory cytokines. These results show that experimental ALF leads to increases in brain production of proinflammatory cytokines, and afford the first direct evidence that central inflammatory mechanisms play a role in the pathogenesis of the cerebral complications of ALF. Antiinflammatory agents could be beneficial in the management of these complications." @default.
• W1976467306 created "2016-06-24" @default.
• W1976467306 creator A5031757444 @default.
• W1976467306 creator A5054512866 @default.
• W1976467306 creator A5073384511 @default.
• W1976467306 date "2009-03-04" @default.
• W1976467306 modified "2023-10-18" @default.
• W1976467306 title "Direct Evidence for Central Proinflammatory Mechanisms in Rats with Experimental Acute Liver Failure: Protective Effect of Hypothermia" @default.
• W1976467306 cites W1275160054 @default.
• W1976467306 cites W1573034840 @default.
• W1976467306 cites W168560577 @default.
• W1976467306 cites W1963588191 @default.
• W1976467306 cites W1967081185 @default.
• W1976467306 cites W1972563980 @default.
• W1976467306 cites W1999383618 @default.
• W1976467306 cites W2003188525 @default.
• W1976467306 cites W2008264563 @default.
• W1976467306 cites W2008270378 @default.
• W1976467306 cites W2008390911 @default.
• W1976467306 cites W2010255267 @default.
• W1976467306 cites W2014325254 @default.
• W1976467306 cites W2041254899 @default.
• W1976467306 cites W2048656662 @default.
• W1976467306 cites W2061610324 @default.
• W1976467306 cites W2076858103 @default.
• W1976467306 cites W2079439539 @default.
• W1976467306 cites W2085246488 @default.
• W1976467306 cites W2087148853 @default.
• W1976467306 cites W2108138347 @default.
• W1976467306 cites W2110164053 @default.
• W1976467306 cites W2112610029 @default.
• W1976467306 cites W2124366134 @default.
• W1976467306 cites W2141310528 @default.
• W1976467306 cites W2152074493 @default.
• W1976467306 cites W2157564017 @default.
• W1976467306 cites W2529863675 @default.
• W1976467306 doi "https://doi.org/10.1038/jcbfm.2009.18" @default.
• W1976467306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19259110" @default.
• W1976467306 hasPublicationYear "2009" @default.
• W1976467306 type Work @default.
• W1976467306 sameAs 1976467306 @default.
• W1976467306 citedByCount "113" @default.
• W1976467306 countsByYear W19764673062012 @default.
• W1976467306 countsByYear W19764673062013 @default.
• W1976467306 countsByYear W19764673062014 @default.
• W1976467306 countsByYear W19764673062015 @default.
• W1976467306 countsByYear W19764673062016 @default.
• W1976467306 countsByYear W19764673062017 @default.
• W1976467306 countsByYear W19764673062018 @default.
• W1976467306 countsByYear W19764673062019 @default.
• W1976467306 countsByYear W19764673062020 @default.
• W1976467306 countsByYear W19764673062021 @default.
• W1976467306 countsByYear W19764673062022 @default.
• W1976467306 countsByYear W19764673062023 @default.
• W1976467306 crossrefType "journal-article" @default.
• W1976467306 hasAuthorship W1976467306A5031757444 @default.
• W1976467306 hasAuthorship W1976467306A5054512866 @default.
• W1976467306 hasAuthorship W1976467306A5073384511 @default.
• W1976467306 hasBestOaLocation W19764673061 @default.
• W1976467306 hasConcept C126322002 @default.
• W1976467306 hasConcept C164027704 @default.
• W1976467306 hasConcept C17991360 @default.
• W1976467306 hasConcept C203014093 @default.
• W1976467306 hasConcept C2776914184 @default.
• W1976467306 hasConcept C2777214474 @default.
• W1976467306 hasConcept C2777390192 @default.
• W1976467306 hasConcept C2778621155 @default.
• W1976467306 hasConcept C2779493303 @default.
• W1976467306 hasConcept C2780325230 @default.
• W1976467306 hasConcept C2780942790 @default.
• W1976467306 hasConcept C2781458332 @default.
• W1976467306 hasConcept C71924100 @default.
• W1976467306 hasConceptScore W1976467306C126322002 @default.
• W1976467306 hasConceptScore W1976467306C164027704 @default.
• W1976467306 hasConceptScore W1976467306C17991360 @default.
• W1976467306 hasConceptScore W1976467306C203014093 @default.
• W1976467306 hasConceptScore W1976467306C2776914184 @default.
• W1976467306 hasConceptScore W1976467306C2777214474 @default.
• W1976467306 hasConceptScore W1976467306C2777390192 @default.
• W1976467306 hasConceptScore W1976467306C2778621155 @default.
• W1976467306 hasConceptScore W1976467306C2779493303 @default.
• W1976467306 hasConceptScore W1976467306C2780325230 @default.
• W1976467306 hasConceptScore W1976467306C2780942790 @default.
• W1976467306 hasConceptScore W1976467306C2781458332 @default.
• W1976467306 hasConceptScore W1976467306C71924100 @default.
• W1976467306 hasIssue "5" @default.
• W1976467306 hasLocation W19764673061 @default.
• W1976467306 hasLocation W19764673062 @default.
• W1976467306 hasOpenAccess W1976467306 @default.
• W1976467306 hasPrimaryLocation W19764673061 @default.
• W1976467306 hasRelatedWork W1275160054 @default.
• W1976467306 hasRelatedWork W185755941 @default.
• W1976467306 hasRelatedWork W1986486552 @default.
• W1976467306 hasRelatedWork W2003188525 @default.
• W1976467306 hasRelatedWork W2027698533 @default.
• W1976467306 hasRelatedWork W2061625478 @default.
• W1976467306 hasRelatedWork W2117046272 @default.
• W1976467306 hasRelatedWork W2141310528 @default.

• next