FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976473344> ?p ?o ?g. }

• W1976473344 endingPage "143" @default.
• W1976473344 startingPage "124" @default.
• W1976473344 abstract "The long-standing belief that the spinal cord serves merely as a conduit for information traveling to and from the brain is changing. Over the past decade, research has shown that the spinal cord is sensitive to response-outcome contingencies, demonstrating that spinal circuits have the capacity to modify behavior in response to differential environmental cues. If spinally transected rats are administered shock contingent on leg extension (controllable shock), they will maintain a flexion response that minimizes shock exposure. If, however, this contingency is broken, and shock is administered irrespective of limb position (uncontrollable shock), subjects cannot acquire the same flexion response. Interestingly, each of these treatments has a lasting effect on behavior; controllable shock enables future learning, while uncontrollable shock produces a long-lasting learning deficit. Here we suggest that the mechanisms underlying learning and the deficit may have evolved from machinery responsible for the spinal processing of noxious information. Experiments have shown that learning and the deficit require receptors and signaling cascades shown to be involved in central sensitization, including activation of NMDA and neurokinin receptors, as well as CaMKII. Further supporting this link between pain and learning, research has also shown that uncontrollable stimulation results in allodynia. Moreover, systemic inflammation and neonatal hindpaw injury each facilitate pain responding and undermine the ability of the spinal cord to support learning. These results suggest that the plasticity associated with learning and pain must be placed in a balance in order for adaptive outcomes to be observed." @default.
• W1976473344 created "2016-06-24" @default.
• W1976473344 creator A5018347346 @default.
• W1976473344 creator A5054366002 @default.
• W1976473344 creator A5081950449 @default.
• W1976473344 date "2009-10-01" @default.
• W1976473344 modified "2023-09-27" @default.
• W1976473344 title "Pain and learning in a spinal system: Contradictory outcomes from common origins" @default.
• W1976473344 cites W139097051 @default.
• W1976473344 cites W146740744 @default.
• W1976473344 cites W1531783246 @default.
• W1976473344 cites W1576209550 @default.
• W1976473344 cites W1584461750 @default.
• W1976473344 cites W1588041244 @default.
• W1976473344 cites W1599277155 @default.
• W1976473344 cites W1602103399 @default.
• W1976473344 cites W1612226764 @default.
• W1976473344 cites W1618876594 @default.
• W1976473344 cites W1691247107 @default.
• W1976473344 cites W1712145088 @default.
• W1976473344 cites W1784820495 @default.
• W1976473344 cites W1869612208 @default.
• W1976473344 cites W1949317008 @default.
• W1976473344 cites W1963918819 @default.
• W1976473344 cites W1964303494 @default.
• W1976473344 cites W1964344125 @default.
• W1976473344 cites W1966035156 @default.
• W1976473344 cites W1966237677 @default.
• W1976473344 cites W1966292908 @default.
• W1976473344 cites W1968137478 @default.
• W1976473344 cites W1969225757 @default.
• W1976473344 cites W1969439040 @default.
• W1976473344 cites W1969730957 @default.
• W1976473344 cites W1970085850 @default.
• W1976473344 cites W1970612448 @default.
• W1976473344 cites W1970690750 @default.
• W1976473344 cites W1974907373 @default.
• W1976473344 cites W1976117597 @default.
• W1976473344 cites W1976457897 @default.
• W1976473344 cites W1976568355 @default.
• W1976473344 cites W1977656239 @default.
• W1976473344 cites W1978515480 @default.
• W1976473344 cites W1978858276 @default.
• W1976473344 cites W1979032136 @default.
• W1976473344 cites W1979885252 @default.
• W1976473344 cites W1983285229 @default.
• W1976473344 cites W1983929207 @default.
• W1976473344 cites W1986015487 @default.
• W1976473344 cites W1987781967 @default.
• W1976473344 cites W1988059170 @default.
• W1976473344 cites W1989437705 @default.
• W1976473344 cites W1991095869 @default.
• W1976473344 cites W1991562474 @default.
• W1976473344 cites W1991664084 @default.
• W1976473344 cites W1992296810 @default.
• W1976473344 cites W1992544824 @default.
• W1976473344 cites W1993715556 @default.
• W1976473344 cites W1994472481 @default.
• W1976473344 cites W1994708444 @default.
• W1976473344 cites W1994719876 @default.
• W1976473344 cites W1994768747 @default.
• W1976473344 cites W1996235270 @default.
• W1976473344 cites W1998175383 @default.
• W1976473344 cites W1998197689 @default.
• W1976473344 cites W1998431650 @default.
• W1976473344 cites W1998465031 @default.
• W1976473344 cites W1999810771 @default.
• W1976473344 cites W2003191908 @default.
• W1976473344 cites W2003267228 @default.
• W1976473344 cites W2003372927 @default.
• W1976473344 cites W2003646312 @default.
• W1976473344 cites W2005379540 @default.
• W1976473344 cites W2006348991 @default.
• W1976473344 cites W2008464044 @default.
• W1976473344 cites W2008588148 @default.
• W1976473344 cites W2010560632 @default.
• W1976473344 cites W2010791222 @default.
• W1976473344 cites W2010920096 @default.
• W1976473344 cites W2012174663 @default.
• W1976473344 cites W2013492510 @default.
• W1976473344 cites W2014779151 @default.
• W1976473344 cites W2014864516 @default.
• W1976473344 cites W2015756509 @default.
• W1976473344 cites W2015780545 @default.
• W1976473344 cites W2016043871 @default.
• W1976473344 cites W2018662966 @default.
• W1976473344 cites W2019679796 @default.
• W1976473344 cites W2021160653 @default.
• W1976473344 cites W2021213423 @default.
• W1976473344 cites W2021235911 @default.
• W1976473344 cites W2021723318 @default.
• W1976473344 cites W2024408751 @default.
• W1976473344 cites W2024495984 @default.
• W1976473344 cites W2024953914 @default.
• W1976473344 cites W2025239428 @default.
• W1976473344 cites W2025280287 @default.
• W1976473344 cites W2025801062 @default.
• W1976473344 cites W2026999193 @default.

• next