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- W1976482214 abstract "Les auteurs rapportent trois observations de syndrome de Gougerot-Sjögren primitif chez des mineurs de charbon atteints d'anthracosilicose. Tous les patients remplissaient les critères diagnostiques du syndrome de Gougerot-Sjögren primitif récemment établis par le groupe d'étude de la Communauté européenne. Ils avaient une xérostomie et une xérophtalmie sévères. Un patient avait une cryoglobulinémie et une polynévrite. Un autre avait un phénomène de Raynaud, des arthralgies, un purpura et une polynévrite. La capillaroscopie était normale dans les trois cas, des anticorps antinucléaires étaient détectés chez un seul patient (anticorps anti-SSA et anti-SSB). La prévalence de la sclérodermie systémique, de la polyarthrite rhumatoïde et probablement du lupus érythémateux disséminé est significativement plus élevée après exposition professionnelle prolongée à la silice. En revanche, aucun cas de syndrome de Gougerot-Sjögren primitif associé à une silicose pulmonaire n'a encore été rapporté. Les mécanismes physiopathologiques de ces associations sont mal connus. We report three cases of primary Sjögren's syndrome in silicotic coal miners. All patients fulfilled the diagnostic criteria for Sjögren's syndrome recently established by the European Community study group. One patient had cryoglobulinemia and polynevritis. Another had Raynaud's phenomenom, arthralgia, purpura and polynevritis. Capillary microscopy was normal in all the three patients. Antinuclear antibodies were detected only in one patient, who had also anti-SSa and anti-SSb antibodies. The prevalence of systemic sclerosis, rheumatoid arthritis and probably systemic lupus erythematosus is significantly higher after longstanding occupational exposure to silica. On the contrary, any case of Sjögren's syndrome was till now described in the course of pulmonary silicosis. The physiopathological mechanisms of these associations are misunderstood." @default.
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- W1976482214 date "1994-01-01" @default.
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- W1976482214 title "Silicose et syndrome de Gougerot-Sjögren primitif" @default.
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- W1976482214 doi "https://doi.org/10.1016/s0248-8663(05)82502-0" @default.
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