Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976482767> ?p ?o ?g. }
- W1976482767 endingPage "496" @default.
- W1976482767 startingPage "482" @default.
- W1976482767 abstract "The possibility that a serotonin 5-HT2c receptor-modulating compound, AP-267, will influence spontaneous morphine withdrawal symptoms and the alterations in the brain fluid microenvironment was examined in a rat model. Daily administration of morphine (10 mg/kg, i.p.) for 10 days resulted in dependence of rats as seen by loss of analgesic response. On the 11th day, no morphine administration was given. This resulted in profound withdrawal symptoms 24 h after morphine withdrawal. The magnitude and severity of these symptoms were increased further 48 h after withdrawal. Measurement of the blood-brain barrier (BBB) permeability, a measure of perturbed brain fluid microenvironment showed leakage of Evans blue and radioiodine tracers in several parts of the brain in rats showing withdrawal symptoms. Whereas, rats treated with AP-267 either on the 1st day or 2nd day morphine withdrawal showed much less symptoms and leakage of the BBB. Taken together, these observations suggest that (a) stress associated with the withdrawal symptoms are sufficient enough to induce breakdown of the BBB function, and (b) modulation of serotonin 5-HT2c receptors may have some protective influence on the stress symptoms and the BBB disruption." @default.
- W1976482767 created "2016-06-24" @default.
- W1976482767 creator A5016755104 @default.
- W1976482767 creator A5040048501 @default.
- W1976482767 creator A5070996328 @default.
- W1976482767 creator A5075343449 @default.
- W1976482767 creator A5086496953 @default.
- W1976482767 creator A5087315149 @default.
- W1976482767 creator A5089946625 @default.
- W1976482767 date "2006-08-01" @default.
- W1976482767 modified "2023-09-23" @default.
- W1976482767 title "A Potent Serotonin-Modulating Compound AP-267 Attenuates Morphine Withdrawal-Induced Blood-Brain Barrier Dysfunction in Rats" @default.
- W1976482767 cites W120306277 @default.
- W1976482767 cites W122474338 @default.
- W1976482767 cites W147537944 @default.
- W1976482767 cites W1512007375 @default.
- W1976482767 cites W1535811381 @default.
- W1976482767 cites W1549497398 @default.
- W1976482767 cites W1676833966 @default.
- W1976482767 cites W1849301772 @default.
- W1976482767 cites W1872228006 @default.
- W1976482767 cites W1879390701 @default.
- W1976482767 cites W1926494419 @default.
- W1976482767 cites W1964942970 @default.
- W1976482767 cites W1968611586 @default.
- W1976482767 cites W1972464320 @default.
- W1976482767 cites W1972695634 @default.
- W1976482767 cites W1972990255 @default.
- W1976482767 cites W1977915261 @default.
- W1976482767 cites W1986825091 @default.
- W1976482767 cites W1987682444 @default.
- W1976482767 cites W1989290237 @default.
- W1976482767 cites W1991588033 @default.
- W1976482767 cites W1996504766 @default.
- W1976482767 cites W1998075304 @default.
- W1976482767 cites W1999311858 @default.
- W1976482767 cites W2001548286 @default.
- W1976482767 cites W2009821818 @default.
- W1976482767 cites W2009914768 @default.
- W1976482767 cites W2012134581 @default.
- W1976482767 cites W2012573248 @default.
- W1976482767 cites W2014186540 @default.
- W1976482767 cites W2015025327 @default.
- W1976482767 cites W2026451284 @default.
- W1976482767 cites W2026478831 @default.
- W1976482767 cites W2037435307 @default.
- W1976482767 cites W2049842274 @default.
- W1976482767 cites W2050770407 @default.
- W1976482767 cites W2053071367 @default.
- W1976482767 cites W2054194857 @default.
- W1976482767 cites W2057652311 @default.
- W1976482767 cites W2061485340 @default.
- W1976482767 cites W2063085120 @default.
- W1976482767 cites W2063665561 @default.
- W1976482767 cites W2066571168 @default.
- W1976482767 cites W2079027936 @default.
- W1976482767 cites W2093611661 @default.
- W1976482767 cites W2138116591 @default.
- W1976482767 cites W2144731571 @default.
- W1976482767 cites W2154110961 @default.
- W1976482767 cites W2325067607 @default.
- W1976482767 cites W2499814884 @default.
- W1976482767 cites W427063663 @default.
- W1976482767 doi "https://doi.org/10.1196/annals.1369.049" @default.
- W1976482767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17105947" @default.
- W1976482767 hasPublicationYear "2006" @default.
- W1976482767 type Work @default.
- W1976482767 sameAs 1976482767 @default.
- W1976482767 citedByCount "26" @default.
- W1976482767 countsByYear W19764827672012 @default.
- W1976482767 countsByYear W19764827672014 @default.
- W1976482767 countsByYear W19764827672015 @default.
- W1976482767 countsByYear W19764827672016 @default.
- W1976482767 countsByYear W19764827672017 @default.
- W1976482767 countsByYear W19764827672019 @default.
- W1976482767 countsByYear W19764827672020 @default.
- W1976482767 countsByYear W19764827672021 @default.
- W1976482767 countsByYear W19764827672022 @default.
- W1976482767 countsByYear W19764827672023 @default.
- W1976482767 crossrefType "journal-article" @default.
- W1976482767 hasAuthorship W1976482767A5016755104 @default.
- W1976482767 hasAuthorship W1976482767A5040048501 @default.
- W1976482767 hasAuthorship W1976482767A5070996328 @default.
- W1976482767 hasAuthorship W1976482767A5075343449 @default.
- W1976482767 hasAuthorship W1976482767A5086496953 @default.
- W1976482767 hasAuthorship W1976482767A5087315149 @default.
- W1976482767 hasAuthorship W1976482767A5089946625 @default.
- W1976482767 hasConcept C126322002 @default.
- W1976482767 hasConcept C134018914 @default.
- W1976482767 hasConcept C170493617 @default.
- W1976482767 hasConcept C185592680 @default.
- W1976482767 hasConcept C2775864247 @default.
- W1976482767 hasConcept C2777389121 @default.
- W1976482767 hasConcept C2777649898 @default.
- W1976482767 hasConcept C2778402981 @default.
- W1976482767 hasConcept C2780632750 @default.
- W1976482767 hasConcept C2780820201 @default.
- W1976482767 hasConcept C42219234 @default.