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• W1976489811 abstract "Bacterial pathogens, such as Pseudomonas aeruginosa, readily form biofilms on surfaces, limiting the efficacy of antimicrobial and antibiotic treatments. To mitigate biofilm formation, surfaces are often treated with antimicrobial agents, which have limited lifetime and efficacy. Recent studies have shown that well-ordered topographic patterns can limit bacterial attachment to surfaces and limit biofilm formation. In this study, nano and microscale patterned poly(dimethylsiloxane) surfaces were evaluated for their ability to affect adhesion and biofilm formation by Pseudomonas aeruginosa. Feature size and spacing were varied from 500 nm to 2 μm and included repeating arrays of square pillars, holes, lines and biomimetc Sharklet™ patterns. Bacterial surface adhesion and biofilm formation was assessed in microfluidic flow devices and under static conditions. Attachment profiles under static and fluid flow varied within topography types, sizes and spacing. Pillar structures of all sizes yielded lower surface attachment than line-based patterns and arrays of holes. This trend was also observed for biomimetic Sharklet™ patterns, with reduced bacterial attachment to raised features as compared to recessed features. Notably, none of the topographically patterned surfaces outperformed smooth surfaces (without topography) for resisting cell adhesion. Initial surface attachment patterns were indicative of subsequent biofilm formation and coverage, suggesting a direct role of surface topography in biofilm-based biofouling." @default.
• W1976489811 created "2016-06-24" @default.
• W1976489811 creator A5046312510 @default.
• W1976489811 creator A5050417350 @default.
• W1976489811 creator A5057722271 @default.
• W1976489811 date "2012-12-01" @default.
• W1976489811 modified "2023-09-26" @default.
• W1976489811 title "EFFECT OF TOPOGRAPHICALLY PATTERNED POLY(DIMETHYLSILOXANE) SURFACES ON <i>Pseudomonas aeruginosa</i> ADHESION AND BIOFILM FORMATION" @default.
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• W1976489811 doi "https://doi.org/10.1142/s1793984412420044" @default.
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