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- W1976490116 abstract "The ABC transporter (ATP-binding-cassette transporter) HlyB (haemolysin B) is the central element of a type I secretion machinery, dedicated to the secretion of the toxin HlyA in Escherichia coli. In addition to the ABC transporter, two other indispensable elements are necessary for the secretion of the toxin across two membranes in a single step: the transenvelope protein HlyD and the outer membrane protein TolC. Despite the fact that the hydrolysis of ATP by HlyB fuels secretion of HlyA, the essential features of the underlying transport mechanism remain an enigma. Similar to all other ABC transporters, ranging from bacteria to man, HlyB is composed of two NBDs (nucleotide-binding domains) and two transmembrane domains. Here we summarize our detailed biochemical, biophysical and structural studies aimed at an understanding of the molecular principles of how ATP-hydrolysis is coupled to energy transduction, including the conformational changes occurring during the catalytic cycle, leading to substrate transport. We have obtained individual crystal structures for each single ground state of the catalytic cycle. From these and other biochemical and mutational studies, we shall provide a detailed molecular picture of the steps governing intramolecular communication and the utilization of chemical energy, due to ATP hydrolysis, in relation to resulting structural changes within the NBD. These data will be summarized in a general model to explain how these molecular machines achieve translocation of molecules across biological membranes." @default.
- W1976490116 created "2016-06-24" @default.
- W1976490116 creator A5021945786 @default.
- W1976490116 creator A5047392065 @default.
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- W1976490116 creator A5072826852 @default.
- W1976490116 creator A5078500840 @default.
- W1976490116 date "2005-10-01" @default.
- W1976490116 modified "2023-09-23" @default.
- W1976490116 title "A molecular understanding of the catalytic cycle of the nucleotide-binding domain of the ABC transporter HlyB" @default.
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- W1976490116 cites W1756287317 @default.
- W1976490116 cites W1889077695 @default.
- W1976490116 cites W1892148740 @default.
- W1976490116 cites W1892940702 @default.
- W1976490116 cites W1901154529 @default.
- W1976490116 cites W1927723646 @default.
- W1976490116 cites W1964619751 @default.
- W1976490116 cites W1965364320 @default.
- W1976490116 cites W1968143836 @default.
- W1976490116 cites W1969609100 @default.
- W1976490116 cites W1972171150 @default.
- W1976490116 cites W1973876121 @default.
- W1976490116 cites W1980108836 @default.
- W1976490116 cites W1986729024 @default.
- W1976490116 cites W1987641460 @default.
- W1976490116 cites W1988284346 @default.
- W1976490116 cites W1990456014 @default.
- W1976490116 cites W1992014529 @default.
- W1976490116 cites W1992764122 @default.
- W1976490116 cites W1993213855 @default.
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- W1976490116 cites W2031442221 @default.
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- W1976490116 doi "https://doi.org/10.1042/bst20050990" @default.
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