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- W1976492420 abstract "Transferrin (Tf) is a paradigmatic metalloprotein, which has been extensively studied in the past and still is a focal point of numerous investigation efforts owing to its unique role in iron homeostasis and enormous promise as a component of a wide range of therapies. Electrospray ionization mass spectrometry (ESI MS) is a potent analytical tool that has been used successfully to study various properties of Tf and Tf-based products, ranging from covalent structure and metal binding to conformation and interaction with their physiological partners. Various ESI MS-based techniques produce unique information on Tf properties and behavior that is highly complementary to information provided by other experimental techniques. The experimental ESI MS-based techniques developed for Tf studies are not only useful for understanding of fundamental aspects of the iron-binding properties of this protein and optimizing Tf-based therapeutic products, but can also be applied to study a range of other metalloproteins. This article is part of a Special Issue entitled Transferrins: Molecular mechanisms of iron transport and disorders." @default.
- W1976492420 created "2016-06-24" @default.
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- W1976492420 date "2012-03-01" @default.
- W1976492420 modified "2023-09-27" @default.
- W1976492420 title "Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry" @default.
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- W1976492420 doi "https://doi.org/10.1016/j.bbagen.2011.06.019" @default.
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