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• W1976494159 abstract "To investigate the risk factors for false-negative T-SPOT.TB results in patients with pulmonary TB (PTB) and extra-pulmonary TB (EPTB).Patients with suspected TB who underwent valid T-SPOT.TB tests were prospectively enrolled at Beijing Chest Hospital between November 2012 and November 2013. Basic characters and clinical laboratory findings were compared between true-positive and false-negative T-SPOT.TB groups.Of 1928 suspected TB patients, 774 (530 PTB and 244 EPTB) microbiologically/histopathogenically-confirmed patients (636 culture-confirmed) were analyzed. Forty-six PTB patients (8.7%) and 32 EPTB patients (13.1%) had negative T-SPOT.TB results. Multivariate analysis showed that increased age [odds radio (OR) 2.26, 95% confidence interval (CI) 1.11-4.58], over-weight (BMI ≥ 25 kg/m(2), OR 2.43, 95% CI 1.05-5.63), and a longer period of illness before hospitalization (>6 months, OR 2.46, 95% CI 1.24-4.92) were independent risk factors for false-negative T-SPOT.TB results in PTB patients. In EPTB patients, increased age (OR 2.42, 95% CI 1.09-5.35) also showed an independent association with false-negative T-SPOT.TB results.Careful interpretation of negative T-SPOT.TB results is necessary in older patients with suspected PTB or EPTB, and in PTB patients who are over-weight or have had longer periods of illness before hospitalization." @default.
• W1976494159 created "2016-06-24" @default.
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• W1976494159 date "2015-04-01" @default.
• W1976494159 modified "2023-10-05" @default.
• W1976494159 title "Risk factors for false-negative T-SPOT.TB assay results in patients with pulmonary and extra-pulmonary TB" @default.
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• W1976494159 doi "https://doi.org/10.1016/j.jinf.2014.12.018" @default.
• W1976494159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25597825" @default.
• W1976494159 hasPublicationYear "2015" @default.
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