Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976507886> ?p ?o ?g. }
- W1976507886 endingPage "74" @default.
- W1976507886 startingPage "63" @default.
- W1976507886 abstract "HCV (hepatitis C virus) represents a major global health problem. A consistent body of evidence has been accumulating, suggesting a peculiar overlap between the HCV life cycle and lipid metabolism. This association becomes evident both for the clinical symptoms of HCV infection and the molecular mechanisms underlying the morphogenesis and entry process of this virus. The HCV core–lipid droplets association seems to be central to the HCV morphogenesis process. Moreover, the biogenesis pathway of very-low-density lipoproteins has been shown to be involved in HCV morphogenesis with MTP (microsomal triacylglycerol transfer protein), ApoB (apolipoprotein B) and ApoE (apolipoprotein E) as essential elements in the production of infectious HCV particles. HCV infectivity also correlates with the lipidation status of the particles. Furthermore, some HCV cellular receptors and the regulation of the entry process are also connected to lipoproteins and lipid metabolism. Specifically, lipoproteins modulate the entry process and the cholesterol transporter SR-BI (scavenger receptor class B type I) is a cellular entry factor for HCV. The present review aims to summarize the advances in our understanding of the HCV–lipid metabolism association, which may open new therapeutic avenues." @default.
- W1976507886 created "2016-06-24" @default.
- W1976507886 creator A5073926339 @default.
- W1976507886 creator A5087727909 @default.
- W1976507886 date "2010-01-01" @default.
- W1976507886 modified "2023-09-25" @default.
- W1976507886 title "Role of lipid metabolism in hepatitis C virus assembly and entry" @default.
- W1976507886 cites W1957867949 @default.
- W1976507886 cites W1973250744 @default.
- W1976507886 cites W1975423158 @default.
- W1976507886 cites W1975564745 @default.
- W1976507886 cites W1976598372 @default.
- W1976507886 cites W1980843025 @default.
- W1976507886 cites W1982315879 @default.
- W1976507886 cites W1983702361 @default.
- W1976507886 cites W1986505810 @default.
- W1976507886 cites W1987199366 @default.
- W1976507886 cites W1987959713 @default.
- W1976507886 cites W1988919271 @default.
- W1976507886 cites W1991809658 @default.
- W1976507886 cites W1993281511 @default.
- W1976507886 cites W1993651229 @default.
- W1976507886 cites W1993690048 @default.
- W1976507886 cites W2001771411 @default.
- W1976507886 cites W2002081608 @default.
- W1976507886 cites W2003579943 @default.
- W1976507886 cites W2004817638 @default.
- W1976507886 cites W2006757932 @default.
- W1976507886 cites W2009108547 @default.
- W1976507886 cites W2009911047 @default.
- W1976507886 cites W2011039629 @default.
- W1976507886 cites W2012420380 @default.
- W1976507886 cites W2014060674 @default.
- W1976507886 cites W2015489330 @default.
- W1976507886 cites W2018066700 @default.
- W1976507886 cites W2021199098 @default.
- W1976507886 cites W2022557944 @default.
- W1976507886 cites W2022741181 @default.
- W1976507886 cites W2022869504 @default.
- W1976507886 cites W2029265942 @default.
- W1976507886 cites W2030464734 @default.
- W1976507886 cites W2031602764 @default.
- W1976507886 cites W2036306822 @default.
- W1976507886 cites W2041816303 @default.
- W1976507886 cites W2041818968 @default.
- W1976507886 cites W2042717865 @default.
- W1976507886 cites W2042994480 @default.
- W1976507886 cites W2044193462 @default.
- W1976507886 cites W2044985885 @default.
- W1976507886 cites W2047352444 @default.
- W1976507886 cites W2048974214 @default.
- W1976507886 cites W2049107903 @default.
- W1976507886 cites W2051481258 @default.
- W1976507886 cites W2054862747 @default.
- W1976507886 cites W2057967679 @default.
- W1976507886 cites W2060209229 @default.
- W1976507886 cites W2062741582 @default.
- W1976507886 cites W2066580123 @default.
- W1976507886 cites W2068128206 @default.
- W1976507886 cites W2075147482 @default.
- W1976507886 cites W2075557556 @default.
- W1976507886 cites W2077050067 @default.
- W1976507886 cites W2077675989 @default.
- W1976507886 cites W2080508595 @default.
- W1976507886 cites W2080835548 @default.
- W1976507886 cites W2083811968 @default.
- W1976507886 cites W2091925927 @default.
- W1976507886 cites W2094733152 @default.
- W1976507886 cites W2098079636 @default.
- W1976507886 cites W2103597231 @default.
- W1976507886 cites W2105291849 @default.
- W1976507886 cites W2106399441 @default.
- W1976507886 cites W2106791445 @default.
- W1976507886 cites W2109457390 @default.
- W1976507886 cites W2110671968 @default.
- W1976507886 cites W2110842901 @default.
- W1976507886 cites W2111543371 @default.
- W1976507886 cites W2116192835 @default.
- W1976507886 cites W2118320694 @default.
- W1976507886 cites W2122343128 @default.
- W1976507886 cites W2127274349 @default.
- W1976507886 cites W2132721964 @default.
- W1976507886 cites W2133812749 @default.
- W1976507886 cites W2135336711 @default.
- W1976507886 cites W2138051219 @default.
- W1976507886 cites W2139731250 @default.
- W1976507886 cites W2141398361 @default.
- W1976507886 cites W2143639253 @default.
- W1976507886 cites W2143824349 @default.
- W1976507886 cites W2145642828 @default.
- W1976507886 cites W2147126871 @default.
- W1976507886 cites W2148584142 @default.
- W1976507886 cites W2149951088 @default.
- W1976507886 cites W2151400756 @default.
- W1976507886 cites W2152112546 @default.
- W1976507886 cites W2152238363 @default.
- W1976507886 cites W2154698511 @default.
- W1976507886 cites W2155368883 @default.