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- W1976512547 abstract "Sperm immobilizing activity of three class I antiarrhythmic drugs, quinidine, procainamide, mexiletine, one adrenoceptor blocking drug, labetalol and one calcium channel blocking drug, diltiazem was measured with a trans-membrane migration method. All these drugs immobilized human sperm. Local anaesthetic effect is the underlying mechanism for these drugs to inhibit sperm motility. Sperm immobilization could be a screening test for the local anaesthetic effect of antiarrhythmic drugs.Sperm immobilizing activity of 3 class 1 antiarrhythmic drugs, quinidine, procainamide, mexiletine, 1 adrenoceptor blocking drug, labetalol, and 1 calcium channel blocking drug, diltiazem was measured with a trans-membrane migration method. Fresh human semen samples were collected from healthy donors. At least 4 samples were tested for each drug. All semen samples fulfilled previous criteria for trans-membrane migration studies. The trans-membrane migration method evaluated human sperm motility be measuring the proportion of sperm that moved across a Nuclepore membrane during 2 hours incubation at 37 degrees Centigrade. The concentration of drug that decreased sperm motility to 50% of control (EC50) was obtained from the concentration resonse curve. A paired t-test was used to compare the differences between the potencies of diltiazem in phosphate buffered saline and in 5% ethanol. The concentrations that decreased sperm motility to 50% of control (EC50) were 0.5, 1.2, 1.4, 2.2, 2.8, and 20 mm for quinidine, diltiazem in 5% ethanol, diltiazem in phosphate buffered saline, labetalol, mexiletine, and procainamide respecitvely. The differences between the sperm immobilizing potencies of diltiazem in 5% ethanol and in phosphate buffered saline were not statistically significant at any concentration." @default.
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- W1976512547 date "1984-06-01" @default.
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- W1976512547 title "Local anaesthetic effect of antiarrhythmic drugs and human sperm immobilization: mechanism and application of the interrelationship." @default.
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- W1976512547 doi "https://doi.org/10.1111/j.1365-2125.1984.tb02404.x" @default.
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