FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976526336> ?p ?o ?g. }

• W1976526336 endingPage "8" @default.
• W1976526336 startingPage "1" @default.
• W1976526336 abstract "The effect of magnesium ions on the catalytic activities of the bovine pituitary multicatalytic proteinase complex (MPC) was studied. Mg2+ markedly stimulated the breakdown of dephosphorylated β-casein (caseinolytic activity) and the hydrolysis of CbzLeuLeuGlu-2-naphthylamide (peptidylglutamyl peptide bond hydrolyzing activity) by a 1700-fold purified preparation of MPC. Cleavage of CbzD-AlaLeuArg-2-naphthylamide (trypsin-like activity) was strongly inhibited and cleavage of CbzGlyGlyLeup-nitroanilide (chymotrypsin-like activity) was weakly inhibited. Similar results were produced when enzymatic activities in the absence of Mg2+ were measured at 52 °C rather than at 37 °C. Trace protein impurities were removed by phenyl-Sepharose chromatography. This additional chromatographic step, while not changing the specific activities of hydrolysis of the three synthetic chromogenic substrates, led to a marked activation of the breakdown of dephosphorylated β-casein. Mg2+ was not able to further stimulate the caseinolytic activities of either the phenyl-Sepharose-treated preparation or the preparation measured at 52 °C. Mg2+ therefore converts a “repressed” form of MPC to an “activated” form, possibly by promoting dissociation of a protein inhibitor, and may serve as a physiological regulator of this enzyme complex." @default.
• W1976526336 created "2016-06-24" @default.
• W1976526336 creator A5012410535 @default.
• W1976526336 creator A5043829023 @default.
• W1976526336 creator A5075411333 @default.
• W1976526336 date "1992-04-01" @default.
• W1976526336 modified "2023-10-06" @default.
• W1976526336 title "Enzymatic changes of the bovine pituitary multicatalytic proteinase complex, induced by magnesium ions" @default.
• W1976526336 cites W1490339549 @default.
• W1976526336 cites W1592919876 @default.
• W1976526336 cites W1775749144 @default.
• W1976526336 cites W1835492539 @default.
• W1976526336 cites W1975436203 @default.
• W1976526336 cites W1978138686 @default.
• W1976526336 cites W1984553096 @default.
• W1976526336 cites W1989990175 @default.
• W1976526336 cites W1990011328 @default.
• W1976526336 cites W1991915276 @default.
• W1976526336 cites W1992729611 @default.
• W1976526336 cites W2002053089 @default.
• W1976526336 cites W2007238629 @default.
• W1976526336 cites W2008339836 @default.
• W1976526336 cites W2029604739 @default.
• W1976526336 cites W2034791616 @default.
• W1976526336 cites W2060904575 @default.
• W1976526336 cites W2076099594 @default.
• W1976526336 cites W2077086653 @default.
• W1976526336 cites W2078041074 @default.
• W1976526336 cites W2085847856 @default.
• W1976526336 cites W2087316679 @default.
• W1976526336 cites W2087577799 @default.
• W1976526336 cites W2088191492 @default.
• W1976526336 cites W2090825527 @default.
• W1976526336 cites W2093281074 @default.
• W1976526336 cites W2100837269 @default.
• W1976526336 cites W2322650421 @default.
• W1976526336 cites W2341012934 @default.
• W1976526336 cites W2402077250 @default.
• W1976526336 cites W4252620743 @default.
• W1976526336 doi "https://doi.org/10.1016/0003-9861(92)90128-j" @default.
• W1976526336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1550335" @default.
• W1976526336 hasPublicationYear "1992" @default.
• W1976526336 type Work @default.
• W1976526336 sameAs 1976526336 @default.
• W1976526336 citedByCount "40" @default.
• W1976526336 countsByYear W19765263362019 @default.
• W1976526336 countsByYear W19765263362022 @default.
• W1976526336 crossrefType "journal-article" @default.
• W1976526336 hasAuthorship W1976526336A5012410535 @default.
• W1976526336 hasAuthorship W1976526336A5043829023 @default.
• W1976526336 hasAuthorship W1976526336A5075411333 @default.
• W1976526336 hasConcept C125209161 @default.
• W1976526336 hasConcept C151730666 @default.
• W1976526336 hasConcept C175156509 @default.
• W1976526336 hasConcept C178790620 @default.
• W1976526336 hasConcept C181199279 @default.
• W1976526336 hasConcept C185592680 @default.
• W1976526336 hasConcept C2776142715 @default.
• W1976526336 hasConcept C2779281246 @default.
• W1976526336 hasConcept C2779881004 @default.
• W1976526336 hasConcept C2780340462 @default.
• W1976526336 hasConcept C2781307694 @default.
• W1976526336 hasConcept C43369102 @default.
• W1976526336 hasConcept C43617362 @default.
• W1976526336 hasConcept C543218039 @default.
• W1976526336 hasConcept C55493867 @default.
• W1976526336 hasConcept C86803240 @default.
• W1976526336 hasConcept C94412978 @default.
• W1976526336 hasConceptScore W1976526336C125209161 @default.
• W1976526336 hasConceptScore W1976526336C151730666 @default.
• W1976526336 hasConceptScore W1976526336C175156509 @default.
• W1976526336 hasConceptScore W1976526336C178790620 @default.
• W1976526336 hasConceptScore W1976526336C181199279 @default.
• W1976526336 hasConceptScore W1976526336C185592680 @default.
• W1976526336 hasConceptScore W1976526336C2776142715 @default.
• W1976526336 hasConceptScore W1976526336C2779281246 @default.
• W1976526336 hasConceptScore W1976526336C2779881004 @default.
• W1976526336 hasConceptScore W1976526336C2780340462 @default.
• W1976526336 hasConceptScore W1976526336C2781307694 @default.
• W1976526336 hasConceptScore W1976526336C43369102 @default.
• W1976526336 hasConceptScore W1976526336C43617362 @default.
• W1976526336 hasConceptScore W1976526336C543218039 @default.
• W1976526336 hasConceptScore W1976526336C55493867 @default.
• W1976526336 hasConceptScore W1976526336C86803240 @default.
• W1976526336 hasConceptScore W1976526336C94412978 @default.
• W1976526336 hasIssue "1" @default.
• W1976526336 hasLocation W19765263361 @default.
• W1976526336 hasLocation W19765263362 @default.
• W1976526336 hasOpenAccess W1976526336 @default.
• W1976526336 hasPrimaryLocation W19765263361 @default.
• W1976526336 hasRelatedWork W1958447211 @default.
• W1976526336 hasRelatedWork W2002189973 @default.
• W1976526336 hasRelatedWork W2004728452 @default.
• W1976526336 hasRelatedWork W2058635294 @default.
• W1976526336 hasRelatedWork W2077184224 @default.
• W1976526336 hasRelatedWork W2373897018 @default.
• W1976526336 hasRelatedWork W2386854780 @default.
• W1976526336 hasRelatedWork W3010056926 @default.

• next