FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976533651> ?p ?o ?g. }

• W1976533651 endingPage "79" @default.
• W1976533651 startingPage "73" @default.
• W1976533651 abstract "Alzheimer's dementia (AD) is a degenerative brain disorder characterized mainly by cholinergic failure, but other neuro-transmitters are also deficient especially at late stages of the disease. Misfolded β-amyloid peptide has been identified as a causative agent, however inflammatory changes also play a pivotal role. Even though the most prominent pathology is seen in the cognitive functions, specific abnormalities of the central nervous system (CNS) are also reflected in the periphery, particularly in the immune responses of the body. The aim of this study was to characterize the dopaminergic and serotonergic systems in AD, which are also markedly disrupted along with the hallmark acetyl-choline dysfunction. Peripheral blood mono-nuclear cells (PBMCs) from demented patients were judged against comparison groups including individuals with late-onset depression (LOD), as well as non-demented and non-depressed subjects. Cellular sub-populations were evaluated by mono-clonal antibodies against various cell surface receptors: CD4/CD8 (T-lymphocytes), CD19 (B-lymphocytes), CD14 (monocytes), and CD56 (natural-killer (NK)-cells). The expressions of dopamine D3 and D4, as well as serotonin 5-HT1A, 5-HT2A, 5-HT2B and 5-HT2C were also assessed. There were no significant differences among the study groups with respect to the frequency of the cellular sub-types, however a unique profound increase in 5-HT2C receptor exclusively in NK-cells was observed in AD. The disease-specific expression of 5-HT2C, as well as the NK-cell cyto-toxicity, has been linked with cognitive derangement in dementia. These changes not only corroborate the existence of bi-directional communication between the immune system and the CNS, but also elucidate the role of inflammatory activity in AD pathology, and may serve as potential biomarkers for less invasive and early diagnostic purposes as well." @default.
• W1976533651 created "2016-06-24" @default.
• W1976533651 creator A5008517399 @default.
• W1976533651 creator A5010166635 @default.
• W1976533651 creator A5010992910 @default.
• W1976533651 creator A5015246705 @default.
• W1976533651 creator A5023049674 @default.
• W1976533651 creator A5024250267 @default.
• W1976533651 creator A5028105808 @default.
• W1976533651 creator A5028817297 @default.
• W1976533651 creator A5032503259 @default.
• W1976533651 creator A5039322997 @default.
• W1976533651 creator A5040845311 @default.
• W1976533651 creator A5042058903 @default.
• W1976533651 creator A5049423775 @default.
• W1976533651 creator A5066414193 @default.
• W1976533651 creator A5068952614 @default.
• W1976533651 creator A5074961553 @default.
• W1976533651 creator A5076383244 @default.
• W1976533651 creator A5082202542 @default.
• W1976533651 creator A5085380040 @default.
• W1976533651 date "2012-10-01" @default.
• W1976533651 modified "2023-09-27" @default.
• W1976533651 title "Disease-specific expression of the serotonin-receptor 5-HT2C in natural killer cells in Alzheimer's dementia" @default.
• W1976533651 cites W1552188683 @default.
• W1976533651 cites W1556867369 @default.
• W1976533651 cites W1964624690 @default.
• W1976533651 cites W1971574398 @default.
• W1976533651 cites W1972380966 @default.
• W1976533651 cites W1973383950 @default.
• W1976533651 cites W1978493362 @default.
• W1976533651 cites W1985099594 @default.
• W1976533651 cites W1990642173 @default.
• W1976533651 cites W1991735528 @default.
• W1976533651 cites W1992618987 @default.
• W1976533651 cites W1994067502 @default.
• W1976533651 cites W2008389802 @default.
• W1976533651 cites W2009383033 @default.
• W1976533651 cites W2010370892 @default.
• W1976533651 cites W2016501123 @default.
• W1976533651 cites W2018160200 @default.
• W1976533651 cites W2018624891 @default.
• W1976533651 cites W2023055592 @default.
• W1976533651 cites W2025743038 @default.
• W1976533651 cites W2027484604 @default.
• W1976533651 cites W2029752698 @default.
• W1976533651 cites W2031395338 @default.
• W1976533651 cites W2032501600 @default.
• W1976533651 cites W2039517305 @default.
• W1976533651 cites W2039588423 @default.
• W1976533651 cites W2044390612 @default.
• W1976533651 cites W2052077459 @default.
• W1976533651 cites W2055240126 @default.
• W1976533651 cites W2061419556 @default.
• W1976533651 cites W2061803684 @default.
• W1976533651 cites W2066491797 @default.
• W1976533651 cites W2073029393 @default.
• W1976533651 cites W2073108196 @default.
• W1976533651 cites W2075569340 @default.
• W1976533651 cites W2082099550 @default.
• W1976533651 cites W2083478042 @default.
• W1976533651 cites W2087733740 @default.
• W1976533651 cites W2092305254 @default.
• W1976533651 cites W2096144352 @default.
• W1976533651 cites W2096410114 @default.
• W1976533651 cites W2105812745 @default.
• W1976533651 cites W2106931873 @default.
• W1976533651 cites W2110897038 @default.
• W1976533651 cites W2113839148 @default.
• W1976533651 cites W2115650832 @default.
• W1976533651 cites W2117317533 @default.
• W1976533651 cites W2125282506 @default.
• W1976533651 cites W2140516726 @default.
• W1976533651 cites W2144239512 @default.
• W1976533651 cites W2147283387 @default.
• W1976533651 cites W2148272634 @default.
• W1976533651 cites W2157291375 @default.
• W1976533651 cites W2169152986 @default.
• W1976533651 cites W2170139582 @default.
• W1976533651 cites W37637289 @default.
• W1976533651 cites W4211079490 @default.
• W1976533651 doi "https://doi.org/10.1016/j.jneuroim.2012.06.003" @default.
• W1976533651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22766135" @default.
• W1976533651 hasPublicationYear "2012" @default.
• W1976533651 type Work @default.
• W1976533651 sameAs 1976533651 @default.
• W1976533651 citedByCount "18" @default.
• W1976533651 countsByYear W19765336512012 @default.
• W1976533651 countsByYear W19765336512013 @default.
• W1976533651 countsByYear W19765336512014 @default.
• W1976533651 countsByYear W19765336512015 @default.
• W1976533651 countsByYear W19765336512016 @default.
• W1976533651 countsByYear W19765336512017 @default.
• W1976533651 countsByYear W19765336512020 @default.
• W1976533651 countsByYear W19765336512022 @default.
• W1976533651 crossrefType "journal-article" @default.
• W1976533651 hasAuthorship W1976533651A5008517399 @default.
• W1976533651 hasAuthorship W1976533651A5010166635 @default.

• next