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- W1976535296 abstract "Immunocytochemical and morphometric methods were applied to study the response of the pituitary to 10 μg Cd/l during the early development of tilapia (Oreochromis mossambicus). The affinity of prolactin (PRL) cells and adrenocorticotropic hormone (ACTH) cells for immunocytochemical staining and percentage of the pituitary volume occupied by these cells (fractional volume) were used as criteria for their activity and related to survival and to tissue Na, K, Ca and water content. Exposure of embryos to Cd led, between 144 h and 288 h after fertilization, to a higher staining intensity and a significant (P < 0.01) increase in fractional volume of PRL cells, indicating a higher synthesizing capacity. No such changes were observed for ACTH cells during the experimental period. Immediately after hatching a significant drop in survival (P < 0.05) and tissue Ca-content (P < 0.01) was observed in Cd-exposed larvae, followed by complete recovery around 216 h and 288 h, respectively. This recovery was concomitant with an apparent increase in the synthesizing capacity of PRL cells, suggesting a decisive role of PRL at a very early stage of development to counteract adverse effects of Cd." @default.
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- W1976535296 date "1990-01-01" @default.
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- W1976535296 title "Pituitary response to cadmium during the early development of tilapia (Oreochromis mossambicus)" @default.
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- W1976535296 doi "https://doi.org/10.1016/0166-445x(90)90073-x" @default.
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