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• W1976541419 abstract "The perifornical area in the posterior lateral hypothalamus (PeFLH) has been implicated in several physiological functions including the sleep-wakefulness regulation. The PeFLH area contains several cell types including those expressing orexins (Orx; also known as hypocretins), mainly located in the PeF nucleus. The aim of the present study was to elucidate the synaptic interactions between Orx neurons located in the PeFLH area and different brainstem neurons involved in the generation of wakefulness and sleep stages such as the locus coeruleus (LC) nucleus (contributing to wakefulness) and the oral pontine reticular nucleus (PnO) nucleus (contributing to REM sleep) Anatomical data demonstrated the existence of a neuronal network involving the PeFLH area, LC and the PnO nuclei that would control the sleep-wake cycle. Electrophysiological experiments indicated that PeFLH area had an excitatory effect on LC neurons. PeFLH stimulation increased the firing rate of LC neurons and induced an activation of the EEG. The excitatory effect evoked by PeFLH stimulation in LC neurons was blocked by the injection of the Orx-1 receptor antagonist SB-334867 into the LC. Similar electrical stimulation of the PeFLH area evoked an inhibition of PnO neurons by activation of GABAergic receptors because the effect was blocked by bicuculline application into the PnO. Our data also revealed that the LC and PnO nuclei exerted a feedback control on neuronal activity of PeFLH area. Electrical stimulation of LC facilitated firing activity of PeFLH neurons by activation of catecholaminergic receptors whereas PnO stimulation inhibited PeFLH neurons by activation of GABAergic receptors. In conclusion, Orx neurons of the PeFLH area seem to be an important organizer of the wakefulness and sleep stages in order to maintain a normal succession of stages during the sleep-wakefulness cycle." @default.
• W1976541419 created "2016-06-24" @default.
• W1976541419 creator A5012226268 @default.
• W1976541419 creator A5038134489 @default.
• W1976541419 creator A5063673202 @default.
• W1976541419 creator A5067197537 @default.
• W1976541419 date "2013-01-01" @default.
• W1976541419 modified "2023-09-23" @default.
• W1976541419 title "Synaptic interactions between perifornical lateral hypothalamic area, locus coeruleus nucleus and the oral pontine reticular nucleus are implicated in the stage succession during sleep-wakefulness cycle" @default.
• W1976541419 cites W1519232679 @default.
• W1976541419 cites W1627229807 @default.
• W1976541419 cites W1892401711 @default.
• W1976541419 cites W1970010492 @default.
• W1976541419 cites W1970493097 @default.
• W1976541419 cites W1972967055 @default.
• W1976541419 cites W1977320288 @default.
• W1976541419 cites W1978082185 @default.
• W1976541419 cites W1979801486 @default.
• W1976541419 cites W1981775108 @default.
• W1976541419 cites W1983298714 @default.
• W1976541419 cites W1989416541 @default.
• W1976541419 cites W1989621915 @default.
• W1976541419 cites W2001327869 @default.
• W1976541419 cites W2010200492 @default.
• W1976541419 cites W2013655437 @default.
• W1976541419 cites W2016378735 @default.
• W1976541419 cites W2018297310 @default.
• W1976541419 cites W2026400531 @default.
• W1976541419 cites W2027609687 @default.
• W1976541419 cites W2027740042 @default.
• W1976541419 cites W2028121897 @default.
• W1976541419 cites W2028256055 @default.
• W1976541419 cites W2029126668 @default.
• W1976541419 cites W2029703642 @default.
• W1976541419 cites W2030956580 @default.
• W1976541419 cites W2031462960 @default.
• W1976541419 cites W2032202532 @default.
• W1976541419 cites W2035973001 @default.
• W1976541419 cites W2038008568 @default.
• W1976541419 cites W2041511326 @default.
• W1976541419 cites W2041731336 @default.
• W1976541419 cites W2044584315 @default.
• W1976541419 cites W2046265271 @default.
• W1976541419 cites W2049088920 @default.
• W1976541419 cites W2050003210 @default.
• W1976541419 cites W2059031913 @default.
• W1976541419 cites W2070356876 @default.
• W1976541419 cites W2072154498 @default.
• W1976541419 cites W2073030636 @default.
• W1976541419 cites W2076814192 @default.
• W1976541419 cites W2078687972 @default.
• W1976541419 cites W2085483223 @default.
• W1976541419 cites W2085712847 @default.
• W1976541419 cites W2088490533 @default.
• W1976541419 cites W2089101037 @default.
• W1976541419 cites W2089183115 @default.
• W1976541419 cites W2093069882 @default.
• W1976541419 cites W2094316274 @default.
• W1976541419 cites W2100743305 @default.
• W1976541419 cites W2102546242 @default.
• W1976541419 cites W2102884007 @default.
• W1976541419 cites W2104729844 @default.
• W1976541419 cites W2107100408 @default.
• W1976541419 cites W2107616890 @default.
• W1976541419 cites W2108773062 @default.
• W1976541419 cites W2109152172 @default.
• W1976541419 cites W2109420778 @default.
• W1976541419 cites W2110175860 @default.
• W1976541419 cites W2110670465 @default.
• W1976541419 cites W2116190393 @default.
• W1976541419 cites W2117213785 @default.
• W1976541419 cites W2120543763 @default.
• W1976541419 cites W2124865173 @default.
• W1976541419 cites W2126279773 @default.
• W1976541419 cites W2128411903 @default.
• W1976541419 cites W2131446846 @default.
• W1976541419 cites W2131498774 @default.
• W1976541419 cites W2141915457 @default.
• W1976541419 cites W2143557510 @default.
• W1976541419 cites W2144249632 @default.
• W1976541419 cites W2152211310 @default.
• W1976541419 cites W2159953069 @default.
• W1976541419 cites W2163815564 @default.
• W1976541419 cites W2164153190 @default.
• W1976541419 cites W2169378022 @default.
• W1976541419 cites W2486585976 @default.
• W1976541419 cites W81777342 @default.
• W1976541419 doi "https://doi.org/10.3389/fnins.2013.00216" @default.
• W1976541419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3832796" @default.
• W1976541419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24311996" @default.
• W1976541419 hasPublicationYear "2013" @default.
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