Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976541550> ?p ?o ?g. }
- W1976541550 endingPage "18897" @default.
- W1976541550 startingPage "18892" @default.
- W1976541550 abstract "Significance Comparing human blood cell types, nuclear diversity is visually striking but unexplained: quasi-spherical nuclei in stem/progenitor cells and T cells contrast with multilobed nuclei in neutrophils, giant nuclei in megakaryocytes, and anuclear erythrocytes. We hypothesized broad roles for the major nuclear structure proteins—lamins—and developed mass spectrometry-calibrated intracellular flow cytometry to quantify lamin-A:B ratios. This ratio controls both nuclear viscoelasticity and cell trafficking across microporous barriers. High A:B rigidifies erythroblast nuclei to favor marrow retention and also enhances erythropoiesis. Intermediate A:B enhances thrombopoiesis and opposes cell division to favor marrow anchorage of megakaryocytes. Human stem/progenitor cells have moderate lamin levels and reside in marrow whereas white cells are favored by low lamins and predominantly circulate." @default.
- W1976541550 created "2016-06-24" @default.
- W1976541550 creator A5034746599 @default.
- W1976541550 creator A5041290018 @default.
- W1976541550 creator A5041933853 @default.
- W1976541550 creator A5044277046 @default.
- W1976541550 creator A5074125956 @default.
- W1976541550 creator A5089735895 @default.
- W1976541550 date "2013-11-04" @default.
- W1976541550 modified "2023-10-10" @default.
- W1976541550 title "Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells" @default.
- W1976541550 cites W1526450413 @default.
- W1976541550 cites W1909554228 @default.
- W1976541550 cites W1967467568 @default.
- W1976541550 cites W196867602 @default.
- W1976541550 cites W1983057459 @default.
- W1976541550 cites W1984340155 @default.
- W1976541550 cites W1994227421 @default.
- W1976541550 cites W2001295746 @default.
- W1976541550 cites W2008178606 @default.
- W1976541550 cites W2009811047 @default.
- W1976541550 cites W2015383096 @default.
- W1976541550 cites W2018275041 @default.
- W1976541550 cites W2019372604 @default.
- W1976541550 cites W2030637965 @default.
- W1976541550 cites W2047088080 @default.
- W1976541550 cites W2050838528 @default.
- W1976541550 cites W2052373675 @default.
- W1976541550 cites W2052849004 @default.
- W1976541550 cites W2054591530 @default.
- W1976541550 cites W2056439533 @default.
- W1976541550 cites W2061688767 @default.
- W1976541550 cites W2063347291 @default.
- W1976541550 cites W2065401691 @default.
- W1976541550 cites W2073460054 @default.
- W1976541550 cites W2074812494 @default.
- W1976541550 cites W2088969742 @default.
- W1976541550 cites W2101083045 @default.
- W1976541550 cites W2118644071 @default.
- W1976541550 cites W2119526996 @default.
- W1976541550 cites W2146455279 @default.
- W1976541550 cites W2148302734 @default.
- W1976541550 cites W2150054925 @default.
- W1976541550 cites W2156812533 @default.
- W1976541550 cites W2172002964 @default.
- W1976541550 cites W2327237185 @default.
- W1976541550 cites W4211059758 @default.
- W1976541550 cites W4247479497 @default.
- W1976541550 cites W436126 @default.
- W1976541550 cites W60057279 @default.
- W1976541550 doi "https://doi.org/10.1073/pnas.1304996110" @default.
- W1976541550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3839750" @default.
- W1976541550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24191023" @default.
- W1976541550 hasPublicationYear "2013" @default.
- W1976541550 type Work @default.
- W1976541550 sameAs 1976541550 @default.
- W1976541550 citedByCount "158" @default.
- W1976541550 countsByYear W19765415502013 @default.
- W1976541550 countsByYear W19765415502014 @default.
- W1976541550 countsByYear W19765415502015 @default.
- W1976541550 countsByYear W19765415502016 @default.
- W1976541550 countsByYear W19765415502017 @default.
- W1976541550 countsByYear W19765415502018 @default.
- W1976541550 countsByYear W19765415502019 @default.
- W1976541550 countsByYear W19765415502020 @default.
- W1976541550 countsByYear W19765415502021 @default.
- W1976541550 countsByYear W19765415502022 @default.
- W1976541550 countsByYear W19765415502023 @default.
- W1976541550 crossrefType "journal-article" @default.
- W1976541550 hasAuthorship W1976541550A5034746599 @default.
- W1976541550 hasAuthorship W1976541550A5041290018 @default.
- W1976541550 hasAuthorship W1976541550A5041933853 @default.
- W1976541550 hasAuthorship W1976541550A5044277046 @default.
- W1976541550 hasAuthorship W1976541550A5074125956 @default.
- W1976541550 hasAuthorship W1976541550A5089735895 @default.
- W1976541550 hasBestOaLocation W19765415501 @default.
- W1976541550 hasConcept C104317684 @default.
- W1976541550 hasConcept C109159458 @default.
- W1976541550 hasConcept C126322002 @default.
- W1976541550 hasConcept C142669718 @default.
- W1976541550 hasConcept C1491633281 @default.
- W1976541550 hasConcept C179093185 @default.
- W1976541550 hasConcept C201750760 @default.
- W1976541550 hasConcept C203014093 @default.
- W1976541550 hasConcept C2776958478 @default.
- W1976541550 hasConcept C2778248108 @default.
- W1976541550 hasConcept C2779703530 @default.
- W1976541550 hasConcept C2779705218 @default.
- W1976541550 hasConcept C2780007613 @default.
- W1976541550 hasConcept C2780723820 @default.
- W1976541550 hasConcept C28328180 @default.
- W1976541550 hasConcept C2909030593 @default.
- W1976541550 hasConcept C29512474 @default.
- W1976541550 hasConcept C54355233 @default.
- W1976541550 hasConcept C71924100 @default.
- W1976541550 hasConcept C78383274 @default.
- W1976541550 hasConcept C86339819 @default.
- W1976541550 hasConcept C86803240 @default.