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• W1976549757 abstract "The majority of folates existing in nature are of the pteroylpolyglutamyl form and are unable to support Lactobacillus casei growth until the δ-linked glutamyls are digested by conjugase enzymes. Most studies involving folate absorption have utilized monoglutamyl forms of folate, primarily folic acid. Synthetic pteroylpolyglutamates prepared by solid phase or conventional synthesis provided conjugated materials with which to study the absorption and metabolism of natural derivatives; however, the synthetic hepataglutamates support microbiological growth prior to enzymatic hydrolysis where as the natural conjugates do not. Incomplete purification of intermediate peptides during the synthesis would be the most likely explanation of this growth phenomenon. A modified solution synthesis has been developed which improves upon intermediate peptide condensations, increases product yields, and provides a heptapeptide which does not support microbiological growth until after enzymatic hydrolysis." @default.
• W1976549757 created "2016-06-24" @default.
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• W1976549757 date "1989-07-01" @default.
• W1976549757 modified "2023-09-23" @default.
• W1976549757 title "Improved conventional synthesis for 14C-labeled polyglutamates of folic acid" @default.
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• W1976549757 doi "https://doi.org/10.1002/jlcr.2580270702" @default.
• W1976549757 hasPublicationYear "1989" @default.
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