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- W1976550238 abstract "The functions, structure and biochemistry of the insect cuticle in relation to the moulting cycle are briefly reviewed as an introduction to the actions of insecticides that act on the cuticle, particularly acylureas. The symptoms of poisoning with diflubenzuron (DFB) and other acylureas are consistent with ultra-structural and biochemical evidence that these insecticides inhibit the formation of chitin microfibrils in newly synthesised cuticle. It is probable that DFB acts at a late stage in chitin biosynthesis, perhaps inhibiting chitin synthase (CS) itself. However, the results of studies using cell-free preparations of CS have not, on the whole, supported this hypothesis. A number of alternative suggestions as to the mode of action of DFB are reviewed. Among the most attractive of these is the possibility that DFB may inhibit the transmembrane transport of chitin synthesis precursors from their site of production within the epidermal cells to the site of the final poly condensation reaction, presumably at the apical membrane of the epidermal microvilli." @default.
- W1976550238 created "2016-06-24" @default.
- W1976550238 creator A5010954788 @default.
- W1976550238 date "1987-01-01" @default.
- W1976550238 modified "2023-10-01" @default.
- W1976550238 title "The cuticle, growth and moulting in insects: The essential background to the action of acylurea insecticides" @default.
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- W1976550238 doi "https://doi.org/10.1002/ps.2780200207" @default.
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