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• W1976551491 abstract "The cDNA encoding human DNA helicase IV (HDH IV), a 100-kDa protein which unwinds DNA in the 5′ to 3′ direction with respect to the bound strand, was cloned and sequenced. It was found to be identical to the human cDNA encoding nucleolin, a ubiquitous eukaryotic protein essential for pre-ribosome assembly. HDH IV/nucleolin can unwind RNA-RNA duplexes, as well as DNA-DNA and DNA-RNA duplexes. Phosphorylation of HDH IV/nucleolin by cdc2 kinase and casein kinase II enhanced its unwinding activity in an additive way. The Gly-rich C-terminal domain possesses a limited ATP-dependent duplex-unwinding activity which contributes to the helicase activity of HDH IV/nucleolin." @default.
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• W1976551491 date "1995-01-01" @default.
• W1976551491 modified "2023-10-03" @default.
• W1976551491 title "Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylation" @default.
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• W1976551491 doi "https://doi.org/10.1016/0378-1119(95)00207-m" @default.
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