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- W197656001 abstract "Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579." @default.
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- W197656001 date "1993-04-01" @default.
- W197656001 modified "2023-10-18" @default.
- W197656001 title "A breast-ovarian cancer susceptibility gene maps to chromosome 17q21." @default.
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