Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976564658> ?p ?o ?g. }
- W1976564658 endingPage "447" @default.
- W1976564658 startingPage "437" @default.
- W1976564658 abstract "In metazoans, microRNAs (miRNAs) carry out various regulatory functions through association with multiprotein miRNA-induced silencing complexes (miRISCs) that contain Dicer and Argonaute proteins. How miRNAs regulate the expression of their mRNA targets remains a major research question. We have identified the C. elegans ain-1 gene through a genetic suppressor screen and shown that it functions with the heterochronic genetic pathway that regulates developmental timing. Biochemical analysis indicates that AIN-1 interacts with protein complexes containing an Argonaute protein, Dicer, and miRNAs. AIN-1 shares homology with the candidate human neurological disease protein GW182, shown to localize in cytoplasmic processing bodies that are sites of mRNA degradation and storage. A functional AIN-1::GFP also localizes at the likely worm processing bodies. When coexpressed from transgenes, AIN-1 targets ALG-1 to the foci. These results suggest a model where AIN-1 regulates a subset of miRISCs by localization to the processing bodies, facilitating degradation or translational inhibition of mRNA targets." @default.
- W1976564658 created "2016-06-24" @default.
- W1976564658 creator A5002073335 @default.
- W1976564658 creator A5004096220 @default.
- W1976564658 creator A5028326859 @default.
- W1976564658 creator A5044511583 @default.
- W1976564658 date "2005-08-01" @default.
- W1976564658 modified "2023-10-14" @default.
- W1976564658 title "The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans" @default.
- W1976564658 cites W144423133 @default.
- W1976564658 cites W1541741307 @default.
- W1976564658 cites W1544882311 @default.
- W1976564658 cites W1581412826 @default.
- W1976564658 cites W1601131608 @default.
- W1976564658 cites W1944127002 @default.
- W1976564658 cites W1946787458 @default.
- W1976564658 cites W1967467639 @default.
- W1976564658 cites W1969695222 @default.
- W1976564658 cites W1973699456 @default.
- W1976564658 cites W1978337436 @default.
- W1976564658 cites W1986006829 @default.
- W1976564658 cites W1993180746 @default.
- W1976564658 cites W1994955455 @default.
- W1976564658 cites W2007085897 @default.
- W1976564658 cites W2007740186 @default.
- W1976564658 cites W2009796716 @default.
- W1976564658 cites W2013022444 @default.
- W1976564658 cites W2014946489 @default.
- W1976564658 cites W2017184218 @default.
- W1976564658 cites W2019387053 @default.
- W1976564658 cites W2024000520 @default.
- W1976564658 cites W2038766179 @default.
- W1976564658 cites W2050066317 @default.
- W1976564658 cites W2064386997 @default.
- W1976564658 cites W2074915514 @default.
- W1976564658 cites W2075123253 @default.
- W1976564658 cites W2080459765 @default.
- W1976564658 cites W2096688350 @default.
- W1976564658 cites W2109459280 @default.
- W1976564658 cites W2116362436 @default.
- W1976564658 cites W2120809584 @default.
- W1976564658 cites W2121570862 @default.
- W1976564658 cites W2128882718 @default.
- W1976564658 cites W2129832778 @default.
- W1976564658 cites W2131623079 @default.
- W1976564658 cites W2134530067 @default.
- W1976564658 cites W2144038313 @default.
- W1976564658 cites W2144645374 @default.
- W1976564658 cites W2145468604 @default.
- W1976564658 cites W2150770935 @default.
- W1976564658 cites W2150897567 @default.
- W1976564658 cites W2152993806 @default.
- W1976564658 cites W2154841861 @default.
- W1976564658 cites W2155396586 @default.
- W1976564658 cites W2157973383 @default.
- W1976564658 cites W2160467221 @default.
- W1976564658 cites W2162278418 @default.
- W1976564658 cites W2165804743 @default.
- W1976564658 cites W2170722275 @default.
- W1976564658 cites W4241434797 @default.
- W1976564658 cites W4253635773 @default.
- W1976564658 doi "https://doi.org/10.1016/j.molcel.2005.07.013" @default.
- W1976564658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16109369" @default.
- W1976564658 hasPublicationYear "2005" @default.
- W1976564658 type Work @default.
- W1976564658 sameAs 1976564658 @default.
- W1976564658 citedByCount "253" @default.
- W1976564658 countsByYear W19765646582012 @default.
- W1976564658 countsByYear W19765646582013 @default.
- W1976564658 countsByYear W19765646582014 @default.
- W1976564658 countsByYear W19765646582015 @default.
- W1976564658 countsByYear W19765646582016 @default.
- W1976564658 countsByYear W19765646582017 @default.
- W1976564658 countsByYear W19765646582018 @default.
- W1976564658 countsByYear W19765646582019 @default.
- W1976564658 countsByYear W19765646582020 @default.
- W1976564658 countsByYear W19765646582021 @default.
- W1976564658 countsByYear W19765646582022 @default.
- W1976564658 countsByYear W19765646582023 @default.
- W1976564658 crossrefType "journal-article" @default.
- W1976564658 hasAuthorship W1976564658A5002073335 @default.
- W1976564658 hasAuthorship W1976564658A5004096220 @default.
- W1976564658 hasAuthorship W1976564658A5028326859 @default.
- W1976564658 hasAuthorship W1976564658A5044511583 @default.
- W1976564658 hasBestOaLocation W19765646581 @default.
- W1976564658 hasConcept C104317684 @default.
- W1976564658 hasConcept C119056186 @default.
- W1976564658 hasConcept C145059251 @default.
- W1976564658 hasConcept C166703698 @default.
- W1976564658 hasConcept C201853390 @default.
- W1976564658 hasConcept C2776802755 @default.
- W1976564658 hasConcept C2778944004 @default.
- W1976564658 hasConcept C2779867133 @default.
- W1976564658 hasConcept C54355233 @default.
- W1976564658 hasConcept C67705224 @default.
- W1976564658 hasConcept C86803240 @default.
- W1976564658 hasConcept C95444343 @default.
- W1976564658 hasConceptScore W1976564658C104317684 @default.