FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976570036> ?p ?o ?g. }

• W1976570036 endingPage "127" @default.
• W1976570036 startingPage "118" @default.
• W1976570036 abstract "In this study, we aimed to identify the hypoxia-inducible factor-1 (HIF-1) binding motif in human STC1 gene promoter and to characterize the associated gene transactivation mechanism. Using normoxic human nasopharyngeal cancer cells (CNE2), we manipulated the stability of HIF-1α protein by overexpressing HIF-1α or the silencing of prolyl hydroxylase-2 (PHD2), to illustrate HIF-1 activation of STC1 promoter-driven luciferase activity. Subsequently luciferase activities of the deletion and mutated STC1 promoter constructs were investigated in HIF-1 overexpressed cells. The data revealed the presence of an authentic HRE motif in STC1 gene. This result was further supported by the chromatin immunoprecipitation (ChIP) assay. Using a similar experimental treatment, however, had no significant effect on the expression level of STC1 mRNA and protein. Moreover the activation of STC1 expression can be restored by the silencing of “factor inhibiting HIF-1” (FIH-1) in either HIF-1 overexpressed or PHD2 silenced cells. The data implied that the HIF-1-mediated STC1 gene expression required the recruitment of p300. This presumption was confirmed by the use of p300 inhibitor, chetomin and HIF-1α/p300 re-ChIP assay. Collectively our data provide the first evidence to show that STC1 is a FIH-inhibited gene with a functional HRE motif located at the upstream region between −2322/−2335. The data support the need for further investigation to reveal if STC1 can be used as a novel tumor marker for HIF-1 induction and for the monitoring of anti-angiogenic therapy." @default.
• W1976570036 created "2016-06-24" @default.
• W1976570036 creator A5024552217 @default.
• W1976570036 creator A5028630779 @default.
• W1976570036 creator A5044804351 @default.
• W1976570036 creator A5078680760 @default.
• W1976570036 date "2010-01-15" @default.
• W1976570036 modified "2023-10-14" @default.
• W1976570036 title "Identification and characterization of the hypoxia-responsive element in human stanniocalcin-1 gene" @default.
• W1976570036 cites W1509351491 @default.
• W1976570036 cites W1543879113 @default.
• W1976570036 cites W1869391303 @default.
• W1976570036 cites W1916101049 @default.
• W1976570036 cites W1921838585 @default.
• W1976570036 cites W1964197868 @default.
• W1976570036 cites W1968288019 @default.
• W1976570036 cites W1969680903 @default.
• W1976570036 cites W1971228457 @default.
• W1976570036 cites W1973092951 @default.
• W1976570036 cites W1975545468 @default.
• W1976570036 cites W1975984062 @default.
• W1976570036 cites W1977242675 @default.
• W1976570036 cites W1981487137 @default.
• W1976570036 cites W1983075687 @default.
• W1976570036 cites W1985414680 @default.
• W1976570036 cites W1990252717 @default.
• W1976570036 cites W1992426840 @default.
• W1976570036 cites W1993599609 @default.
• W1976570036 cites W1999670368 @default.
• W1976570036 cites W2000272522 @default.
• W1976570036 cites W2003642703 @default.
• W1976570036 cites W2010356452 @default.
• W1976570036 cites W2011768923 @default.
• W1976570036 cites W2012291498 @default.
• W1976570036 cites W2017575850 @default.
• W1976570036 cites W2025086828 @default.
• W1976570036 cites W2025794637 @default.
• W1976570036 cites W2027999430 @default.
• W1976570036 cites W2032389749 @default.
• W1976570036 cites W2032475836 @default.
• W1976570036 cites W2037454422 @default.
• W1976570036 cites W2037867359 @default.
• W1976570036 cites W2038197749 @default.
• W1976570036 cites W2038208040 @default.
• W1976570036 cites W2041771456 @default.
• W1976570036 cites W2041851797 @default.
• W1976570036 cites W2045460249 @default.
• W1976570036 cites W2048216460 @default.
• W1976570036 cites W2051373469 @default.
• W1976570036 cites W2052244380 @default.
• W1976570036 cites W2055635657 @default.
• W1976570036 cites W2058007953 @default.
• W1976570036 cites W2066293337 @default.
• W1976570036 cites W2069468364 @default.
• W1976570036 cites W2069717852 @default.
• W1976570036 cites W2071033926 @default.
• W1976570036 cites W2077783195 @default.
• W1976570036 cites W2080065871 @default.
• W1976570036 cites W2082493554 @default.
• W1976570036 cites W2089692551 @default.
• W1976570036 cites W2095315880 @default.
• W1976570036 cites W2104916769 @default.
• W1976570036 cites W2106250184 @default.
• W1976570036 cites W2111654463 @default.
• W1976570036 cites W2115406537 @default.
• W1976570036 cites W2127430336 @default.
• W1976570036 cites W2134998163 @default.
• W1976570036 cites W2135295352 @default.
• W1976570036 cites W2136495845 @default.
• W1976570036 cites W2137512583 @default.
• W1976570036 cites W2143869281 @default.
• W1976570036 cites W2147432298 @default.
• W1976570036 cites W2152326461 @default.
• W1976570036 cites W2153450922 @default.
• W1976570036 cites W2161765887 @default.
• W1976570036 cites W2168090936 @default.
• W1976570036 doi "https://doi.org/10.1016/j.mce.2009.07.007" @default.
• W1976570036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19628018" @default.
• W1976570036 hasPublicationYear "2010" @default.
• W1976570036 type Work @default.
• W1976570036 sameAs 1976570036 @default.
• W1976570036 citedByCount "44" @default.
• W1976570036 countsByYear W19765700362012 @default.
• W1976570036 countsByYear W19765700362013 @default.
• W1976570036 countsByYear W19765700362014 @default.
• W1976570036 countsByYear W19765700362015 @default.
• W1976570036 countsByYear W19765700362016 @default.
• W1976570036 countsByYear W19765700362017 @default.
• W1976570036 countsByYear W19765700362018 @default.
• W1976570036 countsByYear W19765700362019 @default.
• W1976570036 countsByYear W19765700362020 @default.
• W1976570036 countsByYear W19765700362022 @default.
• W1976570036 countsByYear W19765700362023 @default.
• W1976570036 crossrefType "journal-article" @default.
• W1976570036 hasAuthorship W1976570036A5024552217 @default.
• W1976570036 hasAuthorship W1976570036A5028630779 @default.
• W1976570036 hasAuthorship W1976570036A5044804351 @default.
• W1976570036 hasAuthorship W1976570036A5078680760 @default.

• next