FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976571994> ?p ?o ?g. }

• W1976571994 endingPage "250" @default.
• W1976571994 startingPage "243" @default.
• W1976571994 abstract "Context: Juncus effusus L. var. decipiens BUCHEN. f. leschenaultii GAY has been used in traditional medicine for the treatment of anxiety and insomnia.Objective: The objective of this study was to evaluate the effects of ethanol extract from the pith of Juncus effusus (JEE) on anti-inflammatory activities in RAW 264.7 cells.Materials and methods: The production of inflammatory mediators and the underlying mechanisms using 3.1, 6.3, and 12.5 μg/mL concentrations of JEE were investigated. In addition, the topical anti-inflammatory effects of JEE (0.5, 1, and 2 mg/mL) on 12-O-tetradecanoylphorobol-13 acetate (TPA)-induced ear edema and oral administration of JEE (50, 100, and 200 mg/kg) on carrageenan-induced paw-edema were studied in mice.Results: JEE reduced the release of nitric oxide (NO, IC50 value = 1.98 μg/mL), prostaglandin E2 (IC50 value = 5.5 μg/mL), and pro-inflammatory cytokines, IL-1β (IC50 value = 4.74 μg/mL) and IL-6 (IC50 value = 20.48 μg/mL). JEE also suppressed the protein expression of inducible NO synthase and cyclooxygenase-2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Mechanism studies showed attenuation of LPS-induced activation of NF-κB by JEE via abrogation of IκBα degradation and a subsequent decrease in nuclear p65 level. Phosphorylation of all three MAP kinases (ERK, JNK, and p38) in LPS-stimulated RAW 264.7 cells was also suppressed in a dose-dependent manner. In acute inflammation models of mice, topical application (1 and 2 mg) and oral administration (50, 100, and 200 mg/kg) of JEE ameliorated TPA-induced ear edema and carrageenan-induced paw edema, respectively, in dose-dependent manners.Discussion and conclusion: These results indicate that JEE exhibited anti-inflammatory activities by suppressing the production of inflammatory mediators in LPS-stimulated RAW 264.7 cells and by attenuating edema in mice." @default.
• W1976571994 created "2016-06-24" @default.
• W1976571994 creator A5012424400 @default.
• W1976571994 creator A5015360946 @default.
• W1976571994 creator A5019483095 @default.
• W1976571994 creator A5020740314 @default.
• W1976571994 creator A5022899639 @default.
• W1976571994 creator A5056306660 @default.
• W1976571994 date "2015-04-17" @default.
• W1976571994 modified "2023-09-24" @default.
• W1976571994 title "Anti-inflammatory effects of<i>Juncus effusus</i>extract (JEE) on LPS-stimulated RAW 264.7 cells and edema models" @default.
• W1976571994 cites W1534551308 @default.
• W1976571994 cites W1976640635 @default.
• W1976571994 cites W2002427738 @default.
• W1976571994 cites W2019795889 @default.
• W1976571994 cites W2027009883 @default.
• W1976571994 cites W2032596085 @default.
• W1976571994 cites W2042002595 @default.
• W1976571994 cites W2043868065 @default.
• W1976571994 cites W2047593827 @default.
• W1976571994 cites W2050992012 @default.
• W1976571994 cites W2051390158 @default.
• W1976571994 cites W2060630008 @default.
• W1976571994 cites W2062835892 @default.
• W1976571994 cites W2064643153 @default.
• W1976571994 cites W2066747147 @default.
• W1976571994 cites W2071211356 @default.
• W1976571994 cites W2090602346 @default.
• W1976571994 cites W2090703365 @default.
• W1976571994 cites W2093772735 @default.
• W1976571994 cites W2102664760 @default.
• W1976571994 cites W2124085922 @default.
• W1976571994 cites W2138992293 @default.
• W1976571994 cites W2141009029 @default.
• W1976571994 cites W2164516260 @default.
• W1976571994 cites W2165626477 @default.
• W1976571994 cites W2329903786 @default.
• W1976571994 cites W4239251959 @default.
• W1976571994 cites W4255659747 @default.
• W1976571994 doi "https://doi.org/10.3109/13880209.2015.1029053" @default.
• W1976571994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25885933" @default.
• W1976571994 hasPublicationYear "2015" @default.
• W1976571994 type Work @default.
• W1976571994 sameAs 1976571994 @default.
• W1976571994 citedByCount "9" @default.
• W1976571994 countsByYear W19765719942017 @default.
• W1976571994 countsByYear W19765719942018 @default.
• W1976571994 countsByYear W19765719942019 @default.
• W1976571994 countsByYear W19765719942020 @default.
• W1976571994 countsByYear W19765719942022 @default.
• W1976571994 countsByYear W19765719942023 @default.
• W1976571994 crossrefType "journal-article" @default.
• W1976571994 hasAuthorship W1976571994A5012424400 @default.
• W1976571994 hasAuthorship W1976571994A5015360946 @default.
• W1976571994 hasAuthorship W1976571994A5019483095 @default.
• W1976571994 hasAuthorship W1976571994A5020740314 @default.
• W1976571994 hasAuthorship W1976571994A5022899639 @default.
• W1976571994 hasAuthorship W1976571994A5056306660 @default.
• W1976571994 hasConcept C126322002 @default.
• W1976571994 hasConcept C151730666 @default.
• W1976571994 hasConcept C164027704 @default.
• W1976571994 hasConcept C184235292 @default.
• W1976571994 hasConcept C185592680 @default.
• W1976571994 hasConcept C202751555 @default.
• W1976571994 hasConcept C2776914184 @default.
• W1976571994 hasConcept C2777622882 @default.
• W1976571994 hasConcept C2777752497 @default.
• W1976571994 hasConcept C2779343474 @default.
• W1976571994 hasConcept C51551487 @default.
• W1976571994 hasConcept C519581460 @default.
• W1976571994 hasConcept C55493867 @default.
• W1976571994 hasConcept C57074206 @default.
• W1976571994 hasConcept C71924100 @default.
• W1976571994 hasConcept C86803240 @default.
• W1976571994 hasConcept C98274493 @default.
• W1976571994 hasConceptScore W1976571994C126322002 @default.
• W1976571994 hasConceptScore W1976571994C151730666 @default.
• W1976571994 hasConceptScore W1976571994C164027704 @default.
• W1976571994 hasConceptScore W1976571994C184235292 @default.
• W1976571994 hasConceptScore W1976571994C185592680 @default.
• W1976571994 hasConceptScore W1976571994C202751555 @default.
• W1976571994 hasConceptScore W1976571994C2776914184 @default.
• W1976571994 hasConceptScore W1976571994C2777622882 @default.
• W1976571994 hasConceptScore W1976571994C2777752497 @default.
• W1976571994 hasConceptScore W1976571994C2779343474 @default.
• W1976571994 hasConceptScore W1976571994C51551487 @default.
• W1976571994 hasConceptScore W1976571994C519581460 @default.
• W1976571994 hasConceptScore W1976571994C55493867 @default.
• W1976571994 hasConceptScore W1976571994C57074206 @default.
• W1976571994 hasConceptScore W1976571994C71924100 @default.
• W1976571994 hasConceptScore W1976571994C86803240 @default.
• W1976571994 hasConceptScore W1976571994C98274493 @default.
• W1976571994 hasIssue "2" @default.
• W1976571994 hasLocation W19765719941 @default.
• W1976571994 hasLocation W19765719942 @default.
• W1976571994 hasOpenAccess W1976571994 @default.
• W1976571994 hasPrimaryLocation W19765719941 @default.
• W1976571994 hasRelatedWork W1971316357 @default.

• next