Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976596705> ?p ?o ?g. }
- W1976596705 abstract "The organic nitrate pentaerythrityl tetranitrate (PETN) is known to exert long-term antioxidant and antiatherogenic effects by as yet unidentified mechanisms. In cultured endothelial cells derived from human umbilical vein, the active PETN metabolite PETriN (0.01-1 mM) increased heme oxygenase (HO)-1 mRNA and protein levels in a concentration-dependent fashion. HO-1 induction was accompanied by a marked increase in catalytic activity of the enzyme as reflected by enhanced formation of carbon monoxide and bilirubin. Pretreatment with PETriN or bilirubin at low micromolar concentrations protected endothelial cells from hydrogen peroxide-mediated toxicity. HO-1 induction and endothelial protection by PETriN were not mimicked by isosorbide dinitrate, another long-acting nitrate. The present study demonstrates that PETriN stimulates mRNA and protein expression as well as enzymatic activity of the antioxidant defense protein HO-1 in endothelial cells. Increased HO-1 expression and ensuing formation of cytoprotective bilirubin may contribute to and explain the specific antioxidant and antiatherogenic actions of PETN." @default.
- W1976596705 created "2016-06-24" @default.
- W1976596705 creator A5004500107 @default.
- W1976596705 creator A5012217995 @default.
- W1976596705 creator A5022713809 @default.
- W1976596705 creator A5028515366 @default.
- W1976596705 creator A5050015268 @default.
- W1976596705 creator A5072636380 @default.
- W1976596705 creator A5076654859 @default.
- W1976596705 creator A5083304330 @default.
- W1976596705 date "2002-02-01" @default.
- W1976596705 modified "2023-09-23" @default.
- W1976596705 title "Heme Oxygenase-1 Induction May Explain the Antioxidant Profile of Pentaerythrityl Trinitrate" @default.
- W1976596705 cites W1600690434 @default.
- W1976596705 cites W1775870515 @default.
- W1976596705 cites W1821918060 @default.
- W1976596705 cites W1849554878 @default.
- W1976596705 cites W1923972005 @default.
- W1976596705 cites W1966582616 @default.
- W1976596705 cites W1973464565 @default.
- W1976596705 cites W1984983337 @default.
- W1976596705 cites W1990701910 @default.
- W1976596705 cites W1992071813 @default.
- W1976596705 cites W1998672217 @default.
- W1976596705 cites W2002145191 @default.
- W1976596705 cites W2002751444 @default.
- W1976596705 cites W2007954089 @default.
- W1976596705 cites W2041553103 @default.
- W1976596705 cites W2067040292 @default.
- W1976596705 cites W2071812057 @default.
- W1976596705 cites W2073370113 @default.
- W1976596705 cites W2074736115 @default.
- W1976596705 cites W2078836950 @default.
- W1976596705 cites W2081394289 @default.
- W1976596705 cites W2087232979 @default.
- W1976596705 cites W2108655463 @default.
- W1976596705 cites W2120505405 @default.
- W1976596705 cites W2121581904 @default.
- W1976596705 cites W2123008059 @default.
- W1976596705 cites W2136493270 @default.
- W1976596705 cites W2142608732 @default.
- W1976596705 cites W2143286554 @default.
- W1976596705 cites W2145511446 @default.
- W1976596705 cites W2145530136 @default.
- W1976596705 cites W2157341713 @default.
- W1976596705 cites W2159279632 @default.
- W1976596705 cites W2172938682 @default.
- W1976596705 cites W2183552204 @default.
- W1976596705 cites W2187524281 @default.
- W1976596705 cites W2258090718 @default.
- W1976596705 cites W2292783096 @default.
- W1976596705 cites W2329819503 @default.
- W1976596705 cites W2942681878 @default.
- W1976596705 doi "https://doi.org/10.1006/bbrc.2002.6379" @default.
- W1976596705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11820797" @default.
- W1976596705 hasPublicationYear "2002" @default.
- W1976596705 type Work @default.
- W1976596705 sameAs 1976596705 @default.
- W1976596705 citedByCount "45" @default.
- W1976596705 countsByYear W19765967052012 @default.
- W1976596705 countsByYear W19765967052015 @default.
- W1976596705 countsByYear W19765967052016 @default.
- W1976596705 countsByYear W19765967052017 @default.
- W1976596705 countsByYear W19765967052018 @default.
- W1976596705 countsByYear W19765967052019 @default.
- W1976596705 countsByYear W19765967052020 @default.
- W1976596705 countsByYear W19765967052021 @default.
- W1976596705 crossrefType "journal-article" @default.
- W1976596705 hasAuthorship W1976596705A5004500107 @default.
- W1976596705 hasAuthorship W1976596705A5012217995 @default.
- W1976596705 hasAuthorship W1976596705A5022713809 @default.
- W1976596705 hasAuthorship W1976596705A5028515366 @default.
- W1976596705 hasAuthorship W1976596705A5050015268 @default.
- W1976596705 hasAuthorship W1976596705A5072636380 @default.
- W1976596705 hasAuthorship W1976596705A5076654859 @default.
- W1976596705 hasAuthorship W1976596705A5083304330 @default.
- W1976596705 hasConcept C126322002 @default.
- W1976596705 hasConcept C134018914 @default.
- W1976596705 hasConcept C165474305 @default.
- W1976596705 hasConcept C178790620 @default.
- W1976596705 hasConcept C181199279 @default.
- W1976596705 hasConcept C185592680 @default.
- W1976596705 hasConcept C202751555 @default.
- W1976596705 hasConcept C2776217839 @default.
- W1976596705 hasConcept C2777411675 @default.
- W1976596705 hasConcept C2777513400 @default.
- W1976596705 hasConcept C2778004101 @default.
- W1976596705 hasConcept C2778949068 @default.
- W1976596705 hasConcept C2779219270 @default.
- W1976596705 hasConcept C519581460 @default.
- W1976596705 hasConcept C55493867 @default.
- W1976596705 hasConcept C57600042 @default.
- W1976596705 hasConcept C71924100 @default.
- W1976596705 hasConcept C86803240 @default.
- W1976596705 hasConcept C98274493 @default.
- W1976596705 hasConceptScore W1976596705C126322002 @default.
- W1976596705 hasConceptScore W1976596705C134018914 @default.
- W1976596705 hasConceptScore W1976596705C165474305 @default.
- W1976596705 hasConceptScore W1976596705C178790620 @default.
- W1976596705 hasConceptScore W1976596705C181199279 @default.