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- W197659852 abstract "Summary Hyponatraemia is a recognized adverse drug reaction for both citalopram and ramipril even if the documentation for the latter drug is very limited. As of 5 May 2013 there were 56 Individual Case Safety Reports (ICSRs) of hyponatraemia in association with the combination ramipril and citalopram in the WHO Global ICSR Database, VigiBase®. Although not described in the literature a drug interaction between citalopram and ramipril is consistent with known pharmacological properties of the drugs and individuals taking multiple drugs known to cause hyponatraemia is at increased risk. An association is further supported by a plausible time course in some of the ICSRs in VigiBase. This possible effect is probably drug class related rather than substance related and the association should be evaluated further. Introduction Hyponatraemia is a common and sometimes serious electrolyte imbalance ascribed to either water retention (most frequent) or loss of effective solute (sodium and potassium) in excess of water." @default.
- W197659852 created "2016-06-24" @default.
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- W197659852 date "2014-01-01" @default.
- W197659852 modified "2023-09-26" @default.
- W197659852 title "Combined Citalopram and Ramipril treatment - Hyponatraemia" @default.
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- W197659852 hasPublicationYear "2014" @default.
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