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• W1976604408 abstract "Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity. To assess its chemical stability, a study was carried out in which the effect of pH, temperature, ionic strength and buffer concentration on the reaction rate constant kobs were examined. A stability-indicating reversed-phase high performance liquid chromatography (RP-HPLC) system was used. The pH-log kobs degradation profile, obtained at 70°C, shows that clanfenur has its maximum stability in the pH region 4–5. At pH 7, half-lives were calculated by extrapolation of the Arrhenius plot; at 4°C the half-life was calculated to be 141 years and at 25°C 9.5 years. The activation energy was calculated to be 114 kJ/mol. In acidic, neutral, and alkaline media, the ionic strength has no effect on the degradation. The buffer concentration of citrate, phosphate, borate, and carbonate did not affect the value of kobs. An RP-HPLC chromatogram of degraded clanfenur shows the presence of four degradation products, three of which were identified by LC-ESI-MS as p-chloroaniline, p-chlorophenylurea and 2-fluoro-6-dimethylaminobenzamide." @default.
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• W1976604408 date "1999-08-01" @default.
• W1976604408 modified "2023-10-18" @default.
• W1976604408 title "Degradation study of the investigational anticancer drug clanfenur" @default.
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• W1976604408 doi "https://doi.org/10.1016/s0378-5173(99)00160-x" @default.
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