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- W1976611116 abstract "The risk of developing a variety of tumors is increased under the condition of obesity or excess adiposity. Adipose tissue, apart from its critical role as the energy storage depot, contributes to the composition of tumor microenvironment that influences tumor behavior. It has generally been believed that bone marrow cells giving rise to adipocytes are mesenchymal stem cells (MSCs). Our previous study based on a single hematopoietic stem cell (HSC) transplantation model has identified a novel source of adipocytes from HSCs via progenitors for monocytes/macrophages. When cultured under adipogenic conditions, bone marrow-derived monocyte progenitors differentiated into adipocytes that are positive for Oil Red O staining, and secrete various adipokines including adiponectin, HGF, IGF-1 and MCP-1. These HSC-derived adipocytes underwent further maturation when embedded in matrigel and injected subcutaneously into syngeneic C57Bl/6 mice. To better understand the role of HSC-derived adipocytes in tumor progression, we tested the proliferative and migratory capacities of murine melanoma cells (B16F1) and breast cancer cells (EO771) under the influence of HSC-derived adipocytes. Conditioned medium from HSC-derived adipocyte culture (Ad-CM) supported cell proliferation and enhanced cell migration for both tumor types. We found IGF-1 plays a more important role in EO771 cell proliferation and HGF is indispensible for B16F1 cell migration, which correlate with the observations that B16F1 and EO771 cells express significantly more cMet and IGF-1R, respectively. When co-injected with B16F1 or EO771 cells into C57Bl/6 mice, HSC-derived adipocytes accelerated both melanoma and breast tumor growth, with HSC-derived adipocytes being more effective for B16F1 tumor growth than EO771 tumor growth. Taken together, we conclude that HSC-derived adipocytes regulate melanoma and breast tumor progression with different mechanisms. The ongoing work is directed to further delineate the function, mechanism and regulation of HSC-derived adipocytes in different tumor microenvironments. Citation Format: Ying Xiong, Dayvia A. Laws, Amanda C. LaRue. Hematopoietic stem cell-derived adipocytes promote tumor progression. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr A77. doi:10.1158/1538-7445.CHTME14-A77" @default.
- W1976611116 created "2016-06-24" @default.
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- W1976611116 date "2015-01-01" @default.
- W1976611116 modified "2023-09-25" @default.
- W1976611116 title "Abstract A77: Hematopoietic stem cell-derived adipocytes promote tumor progression" @default.
- W1976611116 doi "https://doi.org/10.1158/1538-7445.chtme14-a77" @default.
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