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- W1976623494 abstract "The aim of the present study is to characterize voltage-sensitive macroscopic K+ current (Ik) components in freshly isolated human colonic smooth muscle cells. Ik components were studied by the conventional whole-cell voltage clamp method. We found two main components of Ik · A transient Ik component with fast kinetics, Ik(fi), activated upon a holding potential of Vh = -80 mV and inactivated completely following a 4-second-long prepulse to 0 mV. Iκ(fi) was abolished by Vh = -50 mV, as well as by a pipette solution containing 11 mMEGTA. The second, non-inactivating Ik component, Ik(ni), had comparable amplitudes at Vh = -80 mV and Vh = -50 mV and could not be inactivated completely, even by positive conditioning stimuli. The amplitudes of Ik(ni) depended strongly on the Ca2+ entry, while the amplitudes and the time course of Ik(ni) were modulated mainly by the intracellular Ca2+ concentration. About 80% of Ik(ni) was selectively inhibited by 0.5 μM apamin. IK(fi) was insensitive to apamin and was totally abolished by 20 mMtetraethyl ammonium extracellularly. According to their voltage dependencies, inactivation properties and pharmacological sensitivity to various K+ channels antagonists, these Ik components differ from those described in colonic smooth muscle cells of laboratory animals." @default.
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- W1976623494 date "1997-01-01" @default.
- W1976623494 modified "2023-09-23" @default.
- W1976623494 title "Main Components of Voltage-Sensitive K<sup>+</sup> Currents of the Human Colonic Smooth Muscle Cells" @default.
- W1976623494 doi "https://doi.org/10.1159/000201487" @default.
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