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- W1976626908 endingPage "819" @default.
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- W1976626908 abstract "The monolayer of cells forming the human corneal endothelium is critical to the maintenance of corneal transparency and is not known to regenerate in vivo. Thus, dysfunction of these cells constitutes the most often cited reasons for the 150,000 or so corneal transplants performed yearly. Although current corneal transplantation is more than 90% successful at 1 year, longer term results are not as encouraging with approximately 70% success at 5 years. Nonimmunologic graft failure and allograft endothelial rejection are the main problems. Furthermore, the global shortage of donor corneas greatly restricts several corneal transplantations performed. With advances in understanding corneal endothelial cell biology, it is now possible to cultivate human corneal endothelial cells (HCECs) in vitro, thus providing new opportunities to develop novel tissue-engineered human corneal endothelium. This review will provide an overview of (a) the characteristics of human corneal endothelium; (b) past and present HCECs isolation and culture protocols; (c) various potential carriers for the generation of tissue-engineered corneal endothelium, together with some of the functional studies reported in various animal models; and (d) the current rapid advancements in surgical techniques for keratoplasty. A successful combination of tissue-engineered human corneal endothelium coupled with innovative and groundbreaking surgical procedures will bridge basic research involving cultured HCECs, bringing it from bench to bedside." @default.
- W1976626908 created "2016-06-24" @default.
- W1976626908 creator A5007551999 @default.
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- W1976626908 creator A5048531055 @default.
- W1976626908 creator A5050145910 @default.
- W1976626908 creator A5073702318 @default.
- W1976626908 date "2011-04-27" @default.
- W1976626908 modified "2023-10-06" @default.
- W1976626908 title "Human Corneal Endothelial Cell Expansion for Corneal Endothelium Transplantation: An Overview" @default.
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