Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976656327> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1976656327 endingPage "197" @default.
- W1976656327 startingPage "193" @default.
- W1976656327 abstract "The present study aimed at determining the influence of tension on the responses of arterial smooth muscle to noradrenaline, phenylephrine and angiotensin II. Concentration-response curves to these agonists were obtained in the rat aorta, at two levels of tension: 3 g (29.4 mN) and 0.5 g (4.9 mN). The results obtained show that the maximal responses to the agonists used (in percent of the maximal response to noradrenaline) were significantly larger (P < 0.05) at 3 g than at 0.5 g: 113% versus 66%, respectively, for noradrenaline; 95% versus 59%, respectively, for phenylephrine; 60% versus 24%, respectively, for angiotensin II. In the presence of gadolinium (100 mumol/L)--a mechanogated ion channel blocker--the responses to noradrenaline at 3 g were still significantly larger than responses at 0.5 g: 103% versus 67%, respectively. The compound H-7 (20 mumol/L)--a protein kinase C inhibitor--caused a marked decrease in the maximal responses to noradrenaline at both levels of tension, the responses being reduced to 44% at 3 g and to 20% at 0.5 g. Isradipine (1 mumol/L)--a calcium channel blocker--caused a slight decrease in the responses to noradrenaline at both levels of tension, the responses being reduced to 86% (3 g) and to 50% (0.5 g). In endothelium-free arterial rings, the responses to noradrenaline at 3 g and 0.5 g were also significantly different: 118% versus 80%, respectively. It is concluded that the tension of the arterial wall is a major factor influencing the effects of vasoconstrictor agents; however the mechanisms underlying this supersensitivity at higher tension remain unknown." @default.
- W1976656327 created "2016-06-24" @default.
- W1976656327 creator A5044203588 @default.
- W1976656327 creator A5087337932 @default.
- W1976656327 date "1999-03-04" @default.
- W1976656327 modified "2023-10-13" @default.
- W1976656327 title "The influence of the wall tension on the contractile responses of arteries" @default.
- W1976656327 cites W155668990 @default.
- W1976656327 cites W1983193721 @default.
- W1976656327 cites W1999424050 @default.
- W1976656327 cites W2018750385 @default.
- W1976656327 cites W2024112733 @default.
- W1976656327 cites W2059251213 @default.
- W1976656327 cites W2083672084 @default.
- W1976656327 cites W2126578889 @default.
- W1976656327 doi "https://doi.org/10.1111/j.1472-8206.1999.tb00338.x" @default.
- W1976656327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10226763" @default.
- W1976656327 hasPublicationYear "1999" @default.
- W1976656327 type Work @default.
- W1976656327 sameAs 1976656327 @default.
- W1976656327 citedByCount "3" @default.
- W1976656327 crossrefType "journal-article" @default.
- W1976656327 hasAuthorship W1976656327A5044203588 @default.
- W1976656327 hasAuthorship W1976656327A5087337932 @default.
- W1976656327 hasConcept C103486182 @default.
- W1976656327 hasConcept C126322002 @default.
- W1976656327 hasConcept C134018914 @default.
- W1976656327 hasConcept C170493617 @default.
- W1976656327 hasConcept C185592680 @default.
- W1976656327 hasConcept C2776066529 @default.
- W1976656327 hasConcept C2777952589 @default.
- W1976656327 hasConcept C2779395532 @default.
- W1976656327 hasConcept C2779980429 @default.
- W1976656327 hasConcept C2780356492 @default.
- W1976656327 hasConcept C2781212610 @default.
- W1976656327 hasConcept C2908929049 @default.
- W1976656327 hasConcept C2992686903 @default.
- W1976656327 hasConcept C519063684 @default.
- W1976656327 hasConcept C71924100 @default.
- W1976656327 hasConcept C84393581 @default.
- W1976656327 hasConceptScore W1976656327C103486182 @default.
- W1976656327 hasConceptScore W1976656327C126322002 @default.
- W1976656327 hasConceptScore W1976656327C134018914 @default.
- W1976656327 hasConceptScore W1976656327C170493617 @default.
- W1976656327 hasConceptScore W1976656327C185592680 @default.
- W1976656327 hasConceptScore W1976656327C2776066529 @default.
- W1976656327 hasConceptScore W1976656327C2777952589 @default.
- W1976656327 hasConceptScore W1976656327C2779395532 @default.
- W1976656327 hasConceptScore W1976656327C2779980429 @default.
- W1976656327 hasConceptScore W1976656327C2780356492 @default.
- W1976656327 hasConceptScore W1976656327C2781212610 @default.
- W1976656327 hasConceptScore W1976656327C2908929049 @default.
- W1976656327 hasConceptScore W1976656327C2992686903 @default.
- W1976656327 hasConceptScore W1976656327C519063684 @default.
- W1976656327 hasConceptScore W1976656327C71924100 @default.
- W1976656327 hasConceptScore W1976656327C84393581 @default.
- W1976656327 hasIssue "2" @default.
- W1976656327 hasLocation W19766563271 @default.
- W1976656327 hasLocation W19766563272 @default.
- W1976656327 hasOpenAccess W1976656327 @default.
- W1976656327 hasPrimaryLocation W19766563271 @default.
- W1976656327 hasRelatedWork W1966357256 @default.
- W1976656327 hasRelatedWork W1992220075 @default.
- W1976656327 hasRelatedWork W2003842308 @default.
- W1976656327 hasRelatedWork W2020571025 @default.
- W1976656327 hasRelatedWork W2064236298 @default.
- W1976656327 hasRelatedWork W2091193686 @default.
- W1976656327 hasRelatedWork W2095093072 @default.
- W1976656327 hasRelatedWork W2129759033 @default.
- W1976656327 hasRelatedWork W2151139437 @default.
- W1976656327 hasRelatedWork W2748952813 @default.
- W1976656327 hasVolume "13" @default.
- W1976656327 isParatext "false" @default.
- W1976656327 isRetracted "false" @default.
- W1976656327 magId "1976656327" @default.
- W1976656327 workType "article" @default.