FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976656389> ?p ?o ?g. }

• W1976656389 endingPage "330" @default.
• W1976656389 startingPage "312" @default.
• W1976656389 abstract "Two-component signal transduction systems (2-CS) play an important role in bacterial pathogenesis. In the work presented here, we have studied the effects of a mutation in the Mycobacterium tuberculosis (Mtb) PhoPR 2-CS on the pathogenicity, physiology and global gene expression of this bacterial pathogen. Disruption of PhoPR causes a marked attenuation of growth in macrophages and mice and prevents growth in low-Mg2+ media. The inability to grow in THP-1 macrophages can be partially overcome by the addition of excess Mg2+ during infection. Global transcription assays demonstrate PhoP is a positive transcriptional regulator of several genes, but do not support the hypothesis that the Mtb PhoPR system is sensing Mg2+ starvation, as is the case with the Salmonella typhimurium PhoPQ 2-CS. The genes that were positively regulated include those found in the pks2 and the msl3 gene clusters that encode enzymes for the biosynthesis of sulphatides and diacyltrehalose and polyacyltrehalose respectively. Complementary biochemical studies, in agreement with recent results from another group, indicate that these complex lipids are also absent from the phoP mutant, and the lack of these components in its cell envelope may indirectly cause the mutant's high-Mg2+ growth requirement. The experiments reported here provide functional evidence for the PhoPR 2-CS involvement in Mtb pathogenesis, and they suggest that a major reason for the attenuation observed in the phoP mutant is the absence of certain complex lipids that are known to be important for virulence." @default.
• W1976656389 created "2016-06-24" @default.
• W1976656389 creator A5014442882 @default.
• W1976656389 creator A5031650712 @default.
• W1976656389 creator A5041220789 @default.
• W1976656389 creator A5065179182 @default.
• W1976656389 creator A5081583289 @default.
• W1976656389 creator A5089000697 @default.
• W1976656389 date "2006-02-23" @default.
• W1976656389 modified "2023-10-17" @default.
• W1976656389 title "The <i>Mycobacterium tuberculosis</i> PhoPR two‐component system regulates genes essential for virulence and complex lipid biosynthesis" @default.
• W1976656389 cites W1498580352 @default.
• W1976656389 cites W1501582616 @default.
• W1976656389 cites W1504706957 @default.
• W1976656389 cites W1515987373 @default.
• W1976656389 cites W1546268452 @default.
• W1976656389 cites W1549522998 @default.
• W1976656389 cites W1846680989 @default.
• W1976656389 cites W1896469456 @default.
• W1976656389 cites W1906780201 @default.
• W1976656389 cites W1926098097 @default.
• W1976656389 cites W1966350980 @default.
• W1976656389 cites W1971337268 @default.
• W1976656389 cites W1974402216 @default.
• W1976656389 cites W1974569523 @default.
• W1976656389 cites W1976870904 @default.
• W1976656389 cites W1978632336 @default.
• W1976656389 cites W1988255658 @default.
• W1976656389 cites W1994209758 @default.
• W1976656389 cites W2006463424 @default.
• W1976656389 cites W2007097682 @default.
• W1976656389 cites W2008994306 @default.
• W1976656389 cites W2013908690 @default.
• W1976656389 cites W2025539475 @default.
• W1976656389 cites W2034541624 @default.
• W1976656389 cites W2035651986 @default.
• W1976656389 cites W2038803168 @default.
• W1976656389 cites W2041999173 @default.
• W1976656389 cites W2047433615 @default.
• W1976656389 cites W2048597976 @default.
• W1976656389 cites W2054605756 @default.
• W1976656389 cites W2061645799 @default.
• W1976656389 cites W2065977531 @default.
• W1976656389 cites W2066857552 @default.
• W1976656389 cites W2074936140 @default.
• W1976656389 cites W2075772911 @default.
• W1976656389 cites W2078034003 @default.
• W1976656389 cites W2085662298 @default.
• W1976656389 cites W2087732908 @default.
• W1976656389 cites W2090416400 @default.
• W1976656389 cites W2090902470 @default.
• W1976656389 cites W2094741750 @default.
• W1976656389 cites W2094761728 @default.
• W1976656389 cites W2095156443 @default.
• W1976656389 cites W2096992728 @default.
• W1976656389 cites W2101666067 @default.
• W1976656389 cites W2108868738 @default.
• W1976656389 cites W2109817270 @default.
• W1976656389 cites W2110162664 @default.
• W1976656389 cites W2110485939 @default.
• W1976656389 cites W2114220827 @default.
• W1976656389 cites W2116356176 @default.
• W1976656389 cites W2118424597 @default.
• W1976656389 cites W2120842435 @default.
• W1976656389 cites W2122947253 @default.
• W1976656389 cites W2126722178 @default.
• W1976656389 cites W2131491275 @default.
• W1976656389 cites W2132473872 @default.
• W1976656389 cites W2137930295 @default.
• W1976656389 cites W2138069877 @default.
• W1976656389 cites W2140286346 @default.
• W1976656389 cites W2141490444 @default.
• W1976656389 cites W2141884565 @default.
• W1976656389 cites W2146162915 @default.
• W1976656389 cites W2155767187 @default.
• W1976656389 cites W2157638040 @default.
• W1976656389 cites W2157824802 @default.
• W1976656389 cites W2158023121 @default.
• W1976656389 cites W2160170449 @default.
• W1976656389 cites W2160545120 @default.
• W1976656389 cites W2171600225 @default.
• W1976656389 doi "https://doi.org/10.1111/j.1365-2958.2006.05102.x" @default.
• W1976656389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16573683" @default.
• W1976656389 hasPublicationYear "2006" @default.
• W1976656389 type Work @default.
• W1976656389 sameAs 1976656389 @default.
• W1976656389 citedByCount "346" @default.
• W1976656389 countsByYear W19766563892012 @default.
• W1976656389 countsByYear W19766563892013 @default.
• W1976656389 countsByYear W19766563892014 @default.
• W1976656389 countsByYear W19766563892015 @default.
• W1976656389 countsByYear W19766563892016 @default.
• W1976656389 countsByYear W19766563892017 @default.
• W1976656389 countsByYear W19766563892018 @default.
• W1976656389 countsByYear W19766563892019 @default.
• W1976656389 countsByYear W19766563892020 @default.
• W1976656389 countsByYear W19766563892021 @default.
• W1976656389 countsByYear W19766563892022 @default.

• next