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- W1976666812 abstract "Long term survival data and the therapeutic significance of prednisolone for isolated cardiac sarcoidosis (iCS) has not been established, particularly in the cases with left ventricular (LV) dysfunction (EF < 50%). Moreover, it is difficult to diagnose iCS patients without histological evidence of granulomas. The aim of this study was to assess therapeutic effect and prognosis of iCS. According to clinical criteria, sarcoidosis with CS (sCS) and iCS were diagnosed. iCS cases were examined using cardiac magnetic resonance imaging or 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography. Baseline of brain natriuretic peptide (BNP) were not different between sCS (n=17) and iCS (n=7). After prednisolone treatment, BNP decreased significantly in both groups (sCS: before, 157.3±130.3 pg/ml; after, 108.8±93.7, p=0.01; iCS: before, 317.8±331.2; after, 138.6±161.6, p=0.043). The prognosis demonstrated by Kaplan -Meier curve (40±51.1 months) was not different between sCS (n=30) and iCS (n=11). CS cases not treated by prednisolone showed poorer prognosis (p=0.0069). The patients with LV dysfunction which was not treated by prednisolone had the worst outcome among the all groups (p=0.0011). iCS cases with LV dysfunction initially those suspected with the noninvasive imaging modalities, prednisolone treatment should be considered." @default.
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- W1976666812 date "2014-10-01" @default.
- W1976666812 modified "2023-10-17" @default.
- W1976666812 title "Diagnosis and Treatment of Isolated Cardiac Sarcoidosis" @default.
- W1976666812 doi "https://doi.org/10.1016/j.cardfail.2014.07.410" @default.
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