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• W1976670794 abstract "Human atherosclerotic lesions contain mast cells and immunoglobulin G immune complexes containing oxidized low-density lipoproteins (oxLDL-IgG ICs). Here we studied whether such oxLDL-IgG ICs can activate human mast cells and induce them to express and secrete pro-inflammatory cytokines that are potentially capable of inducing and amplifying atherogenic processes.Incubation of cultured human mast cells in the presence of oxLDL-IgG ICs led to a significant dose-dependent upregulation of the expression and secretion of tumor necrosis factor-alpha (TNF-a) and interleukin-8 (IL-8), and the chemotactic cytokine monocyte chemoattractant protein-1 (MCP-1). The secretory responses were dose-dependent and associated with moderate release of histamine and tryptase, which are preformed mast cell mediators contained in the cytoplasmic secretory granules of the cells. Also native LDL-IgG ICs induced similar pro-inflammatory cytokine response, suggesting that ICs per se are important for the IgG IC-induced mast cell activation.Mast cells in atherosclerotic lesions which also contain oxLDL-IgG ICs may become activated by the ICs and secrete many pro-inflammatory cytokines. Our results suggest that intimal mast cells act as a cellular link between oxLDL-IgG ICs and the inflammatory response in atherosclerosis." @default.
• W1976670794 created "2016-06-24" @default.
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• W1976670794 date "2011-02-01" @default.
• W1976670794 modified "2023-09-25" @default.
• W1976670794 title "OxLDL-IgG immune complexes induce expression and secretion of proatherogenic cytokines by cultured human mast cells" @default.
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• W1976670794 doi "https://doi.org/10.1016/j.atherosclerosis.2010.11.024" @default.
• W1976670794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21163482" @default.
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