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- W1976673412 abstract "Abstract To outline the two compartmental closed model, a study was conducted on nephrectomized dogs with 131I-iothalamate and 125I-serumalbumin. A stable equilibrium was reached rapidly and the intravascular volume was compared with the extracellular volume assessed by iothalamate. However a very slow exponential drop of the equilibrium disagrees with the expected plateau. Electrophoretic studies on iothalamate in plasma and total blood in vitro revealed a splitting off of the label, accounting at least in part for the slow drop of intravascular concentrations and signifies the introduction of iodides into the metabolic pathway of iodine. This process is however slow enough to affect clinical measurements. The developed differential equations account for an ideal situation; further mathematical development opens the two compartmental model. A divergence from the ideal situation permits search for explanations like: unstable iothalamate, inconstant positioned patients or changing glomerular filtration rates during a study. The quantities present at any time in each space are accounted for and also what has been eliminated can be easily assessed. Furthermore, in practice the size of the extracellular space can be determined." @default.
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- W1976673412 date "1975-07-01" @default.
- W1976673412 modified "2023-09-25" @default.
- W1976673412 title "A two compartment model and glomerular filtration rate" @default.
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- W1976673412 doi "https://doi.org/10.1016/0047-0740(75)90026-1" @default.
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