FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976678052> ?p ?o ?g. }

• W1976678052 endingPage "573" @default.
• W1976678052 startingPage "568" @default.
• W1976678052 abstract "With the advent of large-scale genomic analysis, the genetic landscape of glioblastoma (GBM) has become more clear, including characteristic genetic alterations in EGFR. In routine clinical practice, genetic alterations in GBMs are identified using several disparate techniques that consume already limited amounts of tissue and add to overall testing costs. In this study, we sought to determine if the full spectrum of EGFR mutations in GBMs could be detected using a single next generation sequencing (NGS) based oncology assay in 34 consecutive cases. Using a battery of informatics tools to identify single nucleotide variants, insertions and deletions, and amplification (including variants EGFRvIII and EGFRvV), twenty-one of the 34 (62%) individuals had at least one alteration in EGFR by sequencing, consistent with published datasets. Mutations detected include several single nucleotide variants, amplification (confirmed by fluorescence in situ hybridization), and the variants EGFRvIII and EGFRvV (confirmed by multiplex ligation-dependent probe amplification). Here we show that a single NGS assay can identify the full spectrum of relevant EGFR mutations. Overall, sequencing based diagnostics have the potential to maximize the amount of genetic information obtained from GBMs and simultaneously reduce the total time, required specimen material, and costs associated with current multimodality studies." @default.
• W1976678052 created "2016-06-24" @default.
• W1976678052 creator A5024363116 @default.
• W1976678052 creator A5033683673 @default.
• W1976678052 creator A5061624565 @default.
• W1976678052 creator A5071450878 @default.
• W1976678052 date "2015-06-01" @default.
• W1976678052 modified "2023-09-23" @default.
• W1976678052 title "A wide spectrum of EGFR mutations in glioblastoma is detected by a single clinical oncology targeted next-generation sequencing panel" @default.
• W1976678052 cites W1530069278 @default.
• W1976678052 cites W181910992 @default.
• W1976678052 cites W1919257374 @default.
• W1976678052 cites W1976451170 @default.
• W1976678052 cites W1982088425 @default.
• W1976678052 cites W1989891384 @default.
• W1976678052 cites W2022888482 @default.
• W1976678052 cites W2025183726 @default.
• W1976678052 cites W2026920664 @default.
• W1976678052 cites W2040827479 @default.
• W1976678052 cites W2041937775 @default.
• W1976678052 cites W2044060805 @default.
• W1976678052 cites W2052204794 @default.
• W1976678052 cites W2059145105 @default.
• W1976678052 cites W2067183952 @default.
• W1976678052 cites W2085752245 @default.
• W1976678052 cites W2086163049 @default.
• W1976678052 cites W2086983721 @default.
• W1976678052 cites W2091240932 @default.
• W1976678052 cites W2092692114 @default.
• W1976678052 cites W2108234281 @default.
• W1976678052 cites W2109816625 @default.
• W1976678052 cites W2113843552 @default.
• W1976678052 cites W2118151336 @default.
• W1976678052 cites W2119180969 @default.
• W1976678052 cites W2126817554 @default.
• W1976678052 cites W2131117209 @default.
• W1976678052 cites W2131403504 @default.
• W1976678052 cites W2145489645 @default.
• W1976678052 cites W2154397429 @default.
• W1976678052 cites W2155798001 @default.
• W1976678052 cites W2161289668 @default.
• W1976678052 cites W2163676912 @default.
• W1976678052 cites W2168133698 @default.
• W1976678052 cites W2171133933 @default.
• W1976678052 cites W2171777347 @default.
• W1976678052 cites W2330900522 @default.
• W1976678052 doi "https://doi.org/10.1016/j.yexmp.2015.04.006" @default.
• W1976678052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4539240" @default.
• W1976678052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25910966" @default.
• W1976678052 hasPublicationYear "2015" @default.
• W1976678052 type Work @default.
• W1976678052 sameAs 1976678052 @default.
• W1976678052 citedByCount "13" @default.
• W1976678052 countsByYear W19766780522015 @default.
• W1976678052 countsByYear W19766780522016 @default.
• W1976678052 countsByYear W19766780522017 @default.
• W1976678052 countsByYear W19766780522018 @default.
• W1976678052 countsByYear W19766780522019 @default.
• W1976678052 countsByYear W19766780522021 @default.
• W1976678052 crossrefType "journal-article" @default.
• W1976678052 hasAuthorship W1976678052A5024363116 @default.
• W1976678052 hasAuthorship W1976678052A5033683673 @default.
• W1976678052 hasAuthorship W1976678052A5061624565 @default.
• W1976678052 hasAuthorship W1976678052A5071450878 @default.
• W1976678052 hasBestOaLocation W19766780522 @default.
• W1976678052 hasConcept C104317684 @default.
• W1976678052 hasConcept C120599132 @default.
• W1976678052 hasConcept C2776194525 @default.
• W1976678052 hasConcept C2781188995 @default.
• W1976678052 hasConcept C36823959 @default.
• W1976678052 hasConcept C501734568 @default.
• W1976678052 hasConcept C502942594 @default.
• W1976678052 hasConcept C51679486 @default.
• W1976678052 hasConcept C54355233 @default.
• W1976678052 hasConcept C70721500 @default.
• W1976678052 hasConcept C86803240 @default.
• W1976678052 hasConceptScore W1976678052C104317684 @default.
• W1976678052 hasConceptScore W1976678052C120599132 @default.
• W1976678052 hasConceptScore W1976678052C2776194525 @default.
• W1976678052 hasConceptScore W1976678052C2781188995 @default.
• W1976678052 hasConceptScore W1976678052C36823959 @default.
• W1976678052 hasConceptScore W1976678052C501734568 @default.
• W1976678052 hasConceptScore W1976678052C502942594 @default.
• W1976678052 hasConceptScore W1976678052C51679486 @default.
• W1976678052 hasConceptScore W1976678052C54355233 @default.
• W1976678052 hasConceptScore W1976678052C70721500 @default.
• W1976678052 hasConceptScore W1976678052C86803240 @default.
• W1976678052 hasIssue "3" @default.
• W1976678052 hasLocation W19766780521 @default.
• W1976678052 hasLocation W19766780522 @default.
• W1976678052 hasLocation W19766780523 @default.
• W1976678052 hasLocation W19766780524 @default.
• W1976678052 hasOpenAccess W1976678052 @default.
• W1976678052 hasPrimaryLocation W19766780521 @default.
• W1976678052 hasRelatedWork W1769696693 @default.
• W1976678052 hasRelatedWork W1974518907 @default.
• W1976678052 hasRelatedWork W2120057987 @default.
• W1976678052 hasRelatedWork W2170578762 @default.

• next