FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976694080> ?p ?o ?g. }

• W1976694080 endingPage "410" @default.
• W1976694080 startingPage "402" @default.
• W1976694080 abstract "A series of eight transfectant influenza viruses was generated by reverse genetics for studies of the palmitylated cysteine residues in the cytoplasmic tail of the hemagglutinin glycoprotein (HA). Following amplification of these viruses in MDCK cells we found that all had developed an elevated pH of membrane fusion—an unexpected result since previous mutant HA expression studies had shown that substitutions of the cysteine residues had no effect on fusion properties. Sequence analyses revealed that each of the viruses had at least one additional mutation in the ectodomain of HA which was responsible for the increase in fusion pH. Similarly, when we passaged egg-grown wild-type X-31 virus in three different lines of MDCK cells or in MDBK cells, high pH fusion mutants were selected within a few passages in every case. The locations of the substitutions in the HA structure are in or near the “fusion peptide” or at subunit interfaces throughout the length of the trimer—reminiscent of the changes selected in earlier studies on amantadine resistance. The observation that passage of certain viruses in mammalian cells can result in the selection of mutants with elevated fusion pH has potential implications both for reverse genetic experiments and, perhaps more importantly, for the choice of substrates for propagation of vaccine viruses." @default.
• W1976694080 created "2016-06-24" @default.
• W1976694080 creator A5010803082 @default.
• W1976694080 creator A5024433475 @default.
• W1976694080 creator A5060785238 @default.
• W1976694080 creator A5062631592 @default.
• W1976694080 creator A5069412319 @default.
• W1976694080 creator A5090775459 @default.
• W1976694080 date "1997-07-01" @default.
• W1976694080 modified "2023-09-26" @default.
• W1976694080 title "Adaptation of Egg-Grown and Transfectant Influenza Viruses for Growth in Mammalian Cells: Selection of Hemagglutinin Mutants with Elevated pH of Membrane Fusion" @default.
• W1976694080 cites W1580917700 @default.
• W1976694080 cites W1760105922 @default.
• W1976694080 cites W1863094910 @default.
• W1976694080 cites W1931522421 @default.
• W1976694080 cites W1978763290 @default.
• W1976694080 cites W1979537384 @default.
• W1976694080 cites W1981821615 @default.
• W1976694080 cites W1984412128 @default.
• W1976694080 cites W1991978326 @default.
• W1976694080 cites W2010300600 @default.
• W1976694080 cites W2013638224 @default.
• W1976694080 cites W2013889224 @default.
• W1976694080 cites W2018529206 @default.
• W1976694080 cites W2020657836 @default.
• W1976694080 cites W2023222277 @default.
• W1976694080 cites W2029705842 @default.
• W1976694080 cites W2029834160 @default.
• W1976694080 cites W2064805716 @default.
• W1976694080 cites W2070734260 @default.
• W1976694080 cites W2114138957 @default.
• W1976694080 cites W2136830567 @default.
• W1976694080 cites W2145214260 @default.
• W1976694080 cites W2153120954 @default.
• W1976694080 cites W2153564793 @default.
• W1976694080 cites W2159031835 @default.
• W1976694080 cites W2170678600 @default.
• W1976694080 cites W2314863690 @default.
• W1976694080 cites W51253256 @default.
• W1976694080 cites W6092899 @default.
• W1976694080 doi "https://doi.org/10.1006/viro.1997.8626" @default.
• W1976694080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9217063" @default.
• W1976694080 hasPublicationYear "1997" @default.
• W1976694080 type Work @default.
• W1976694080 sameAs 1976694080 @default.
• W1976694080 citedByCount "82" @default.
• W1976694080 countsByYear W19766940802012 @default.
• W1976694080 countsByYear W19766940802013 @default.
• W1976694080 countsByYear W19766940802014 @default.
• W1976694080 countsByYear W19766940802015 @default.
• W1976694080 countsByYear W19766940802016 @default.
• W1976694080 countsByYear W19766940802017 @default.
• W1976694080 countsByYear W19766940802018 @default.
• W1976694080 countsByYear W19766940802019 @default.
• W1976694080 countsByYear W19766940802020 @default.
• W1976694080 countsByYear W19766940802021 @default.
• W1976694080 countsByYear W19766940802022 @default.
• W1976694080 crossrefType "journal-article" @default.
• W1976694080 hasAuthorship W1976694080A5010803082 @default.
• W1976694080 hasAuthorship W1976694080A5024433475 @default.
• W1976694080 hasAuthorship W1976694080A5060785238 @default.
• W1976694080 hasAuthorship W1976694080A5062631592 @default.
• W1976694080 hasAuthorship W1976694080A5069412319 @default.
• W1976694080 hasAuthorship W1976694080A5090775459 @default.
• W1976694080 hasBestOaLocation W19766940801 @default.
• W1976694080 hasConcept C1009742 @default.
• W1976694080 hasConcept C103038307 @default.
• W1976694080 hasConcept C104317684 @default.
• W1976694080 hasConcept C143065580 @default.
• W1976694080 hasConcept C153911025 @default.
• W1976694080 hasConcept C159047783 @default.
• W1976694080 hasConcept C16318435 @default.
• W1976694080 hasConcept C170493617 @default.
• W1976694080 hasConcept C2522874641 @default.
• W1976694080 hasConcept C25365240 @default.
• W1976694080 hasConcept C2778692840 @default.
• W1976694080 hasConcept C501734568 @default.
• W1976694080 hasConcept C54355233 @default.
• W1976694080 hasConcept C81885089 @default.
• W1976694080 hasConcept C86803240 @default.
• W1976694080 hasConcept C92488253 @default.
• W1976694080 hasConceptScore W1976694080C1009742 @default.
• W1976694080 hasConceptScore W1976694080C103038307 @default.
• W1976694080 hasConceptScore W1976694080C104317684 @default.
• W1976694080 hasConceptScore W1976694080C143065580 @default.
• W1976694080 hasConceptScore W1976694080C153911025 @default.
• W1976694080 hasConceptScore W1976694080C159047783 @default.
• W1976694080 hasConceptScore W1976694080C16318435 @default.
• W1976694080 hasConceptScore W1976694080C170493617 @default.
• W1976694080 hasConceptScore W1976694080C2522874641 @default.
• W1976694080 hasConceptScore W1976694080C25365240 @default.
• W1976694080 hasConceptScore W1976694080C2778692840 @default.
• W1976694080 hasConceptScore W1976694080C501734568 @default.
• W1976694080 hasConceptScore W1976694080C54355233 @default.
• W1976694080 hasConceptScore W1976694080C81885089 @default.
• W1976694080 hasConceptScore W1976694080C86803240 @default.
• W1976694080 hasConceptScore W1976694080C92488253 @default.
• W1976694080 hasIssue "2" @default.

• next