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• W1976694791 endingPage "5103" @default.
• W1976694791 startingPage "5097" @default.
• W1976694791 abstract "ABSTRACT Serum opacity factor (SOF) is a protein expressed by Streptococcus pyogenes that opacifies mammalian serum. SOF is also a virulence factor of S. pyogenes , but it has not been previously shown to elicit a protective immune response. Herein, we report that SOF evokes bactericidal antibodies against S. pyogenes in humans, rabbits, and mice. Rabbit antiserum against purified recombinant SOF2 opsonized SOF-positive M type 2, 4, and 28 S. pyogenes in human blood but had no effect on SOF-negative M type 5 S. pyogenes . Furthermore, affinity-purified human antibodies against SOF2 also opsonized SOF-positive streptococci. A combination of antisera against M2 and SOF2 proteins was dramatically more effective in killing streptococci than either antiserum alone, indicating that antibodies against SOF2 enhance the opsonic efficiency of M protein antibodies. Mice tolerated an intravenous injection of 100 μg of SOF without overt signs of toxicity, and immunization with SOF protected mice against challenge infections with M type 2 S. pyogenes . These data indicate that SOF evokes opsonic antibodies that may protect against infections by SOF-positive serotypes of group A streptococci and suggest that different serotypes of SOF have common epitopes that may be useful vaccine candidates to protect against group A streptococcal infections." @default.
• W1976694791 created "2016-06-24" @default.
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• W1976694791 date "2003-09-01" @default.
• W1976694791 modified "2023-09-25" @default.
• W1976694791 title "Serum Opacity Factor (SOF) of<i>Streptococcus pyogenes</i>Evokes Antibodies That Opsonize Homologous and Heterologous SOF-Positive Serotypes of Group A Streptococci" @default.
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• W1976694791 doi "https://doi.org/10.1128/iai.71.9.5097-5103.2003" @default.
• W1976694791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/187301" @default.
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