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- W1976697912 abstract "Dopamine (DA) injected unilaterally into the corpus striatum of the brain of the rat after pretreatment with a monoamine oxidase inhibitor, induced contralateral deviation of the head (ED50 = 23 μg). Dopamine, administered similarly into the nucleus accumbens septi, induced strong locomotor arousal effects (ED50 = 32 μg), as reported by others. Systemic administration of the S(+) isomers of apomorphine (APO) and its N-n-propyl analog (NPA) had no significant action on the effects on posture of DA given intrastriatally, even in large doses. In striking contrast, both agents selectively inhibited the locomotor-arousal effects of DA injected into the accumbens, but (+)NPA was seven times more potent (ED50 = 0.5 mgkg vs 16 μg of DA) and its effects lasted for about 70 min. The dose-effect curves for (+)NPA against two doses of DA demonstrated parallel, lateral displacement, indicating a competitive interaction. These results support the impression that enantiomers and analogs of apomorphine, and especially S(+) N-propylnorapomorphine, have potent antidopaminergic actions that may be selective for limbic areas of the forebrain." @default.
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- W1976697912 date "1985-05-01" @default.
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- W1976697912 title "S(+)apomorphines selective inhibition of excitatory effects of dopamine injected into the limbic system of the rat" @default.
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- W1976697912 doi "https://doi.org/10.1016/0028-3908(85)90023-1" @default.
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