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- W1976711089 abstract "Altered redox states such as metabolic acidosis may impair beta-adrenergic receptor responsiveness. Beta-adrenergic receptor function requires formation of a high affinity, “coupled” state of the receptor. The degree of coupling is reflected in the ratio of dissociation constants, KL/KH, for the low and high affinity states of the receptor. It has previously been demonstrated that 16 mM lactate and pH 7.1 induce independent defects in beta-adrenergic receptor function. The purpose of this study was to examine further how endogenous redox agents might alter high affinity state formation. Normal neutrophil membrane preparations containing beta-adrenergic receptors were exposed to several concentrations of three redox couplets native to plasma: lactate (L)-pyruvate (P), beta-hydroxybutyrate (BOHB)-acetoacetate (AcAc), and glutathione (GSH-GSSG). BOHB, AcAc, and P had no isolated effect on high affinity state formation while 10 mM lactate diminished KL/KH by 30% (p < 0.001). Dropping the pH from 7.4 to 7.1 resulted in a 50% to 70% reduction in KL/KH (p < 0.001), independent of metabolite present. GSH or GSSG exposure resulted in a concentration-dependent fall in KL/KH value. Thus, high affinity state formation is regulated by redox couplets and pH independently. The reduced responsiveness of beta-adrenergic receptors observed in such states as metabolic acidosis could result from direct effects of redox couplets in addition to those of low pH." @default.
- W1976711089 created "2016-06-24" @default.
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- W1976711089 date "1986-11-01" @default.
- W1976711089 modified "2023-09-26" @default.
- W1976711089 title "Effects of Endogenous Redox-Active Compounds on Coupling of Human Beta2-Adrenergic Receptors" @default.
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- W1976711089 doi "https://doi.org/10.1097/00000441-198611000-00001" @default.
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